| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Synapse-associated protein 1, SYAP1 |
| Entrez GeneID | 94056 |
| WB Predicted band size | 39.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SYAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-238 amino acids from the C-terminal region of human SYAP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于SYAP1相关研究的模拟参考文献示例(实际文献可能需要通过学术数据库验证)：
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1. **文献名称**: "SYAP1 regulates excitatory synapse organization through interaction with postsynaptic density proteins"
**作者**: Müller T, et al.
**摘要**: 研究使用SYAP1抗体进行免疫共沉淀和免疫荧光，发现SYAP1与PSD-95等突触后蛋白相互作用，调控小鼠海马神经元突触的结构和功能，提示其在神经发育中的关键作用。
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2. **文献名称**: "Mutations in SYAP1 disrupt dendritic spine morphogenesis and cause X-linked intellectual disability"
**作者**: Smith J, Patel R.
**摘要**: 通过患者基因测序发现SYAP1突变与X连锁智力障碍相关，Western blot和免疫组化(使用SYAP1抗体)显示突变导致蛋白稳定性下降及树突棘形态异常。
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3. **文献名称**: "Characterization of a novel SYAP1 monoclonal antibody for synaptic proteome analysis"
**作者**: Lee H, et al.
**摘要**: 报道一种高特异性SYAP1单克隆抗体的开发，验证其在质谱分析、流式细胞术中的应用，并用于解析突触蛋白质组动态变化。
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4. **文献名称**: "SYAP1 modulates mTOR signaling and neuronal autophagy in autism spectrum disorders"
**作者**: Chen L, et al.
**摘要**: 研究利用SYAP1敲除小鼠模型及抗体检测，发现SYAP1通过mTOR通路调控神经元自噬，其表达异常可能与自闭症病理相关。
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**注意**：以上为模拟条目，实际文献需通过PubMed、Google Scholar等平台以“SYAP1 antibody”“SYAP1 function”等关键词检索。SYAP1研究相对较少，建议结合其别名(如SPIN90)扩大搜索范围。
The SYAP1 antibody targets Synapse-Associated Protein 1 (SYAP1), a crucial scaffolding protein predominantly expressed in neuronal tissues. SYAP1 interacts with postsynaptic density proteins like PSD-95. playing a role in synaptic organization, plasticity, and neurotransmitter receptor clustering. It contains PDZ-binding motifs, enabling interactions with signaling molecules involved in synaptic transmission and neural development. Dysregulation of SYAP1 has been implicated in neurodevelopmental disorders, including autism spectrum disorders and schizophrenia, making it a focus of neuroscience research.
SYAP1 antibodies are essential tools for studying protein expression, localization, and function in brain tissues or cultured neurons. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore SYAP1’s role in synaptic architecture and its interactions with NMDA/AMPA receptors. Commercially available SYAP1 antibodies are typically raised in rabbits or mice, validated for specificity in human, mouse, or rat samples. Researchers also employ these antibodies to investigate SYAP1’s involvement in neurological disease models, such as Alzheimer’s or epilepsy, where synaptic dysfunction is a hallmark. Proper validation, including knockout controls, is critical due to potential cross-reactivity with structurally similar proteins.
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