| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glutamate receptor ionotropic, kainate 5, GluK5, Excitatory amino acid receptor 2, EAA2, Glutamate receptor KA-2, KA2, GRIK5, GRIK2 |
| Entrez GeneID | 2901 |
| WB Predicted band size | 109.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GRIK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-129 amino acids from the N-terminal region of human GRIK5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GRIK5 (N-term)抗体的模拟参考文献示例(仅供参考，实际文献需通过数据库检索确认)：
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1. **标题**：*"Selective targeting of GluK5-containing kainate receptors by a custom antibody reveals synaptic localization patterns"*
**作者**：Smith J, et al.
**摘要**：研究利用GRIK5 (N-term)抗体通过免疫组化和超分辨显微技术，揭示了GluK5受体在小鼠海马神经元突触中的特异性分布，并验证了该抗体在阻断受体功能实验中的应用。
2. **标题**：*"Antibody validation for GRIK5 in neurodegenerative disease models"*
**作者**：Lee H, et al.
**摘要**：通过Western blot和免疫沉淀实验，验证了GRIK5 (N-term)抗体在阿尔茨海默病模型中的特异性，发现其能有效检测人脑组织中GluK5蛋白的N端降解片段。
3. **标题**：*"GRIK5 modulates excitatory neurotransmission in autism spectrum disorders: Evidence from antibody-based profiling"*
**作者**：Garcia R, et al.
**摘要**：使用GRIK5 (N-term)抗体对自闭症患者脑组织进行免疫染色，发现GluK5蛋白表达异常与突触过度兴奋相关，提示其病理机制中的潜在作用。
4. **标题**：*"Development of a high-affinity N-terminal antibody for GRIK5 and its application in epilepsy research"*
**作者**：Wang Y, et al.
**摘要**：报道了一种新型GRIK5 (N-term)抗体的开发流程，通过电生理和小鼠癫痫模型证明其能特异性抑制GluK5受体活性，为靶向治疗提供工具。
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**建议**：实际文献可通过PubMed或Google Scholar搜索关键词“GRIK5 antibody N-terminal”“GluK5 antibody validation”等获取。部分商业抗体网站(如CiteAb)也会列出用户发表的相关文献。
The GRIK5 (N-term) antibody is designed to target the N-terminal region of the glutamate ionotropic receptor kainate type subunit 5 (GRIK5), also known as GluK5. This protein is encoded by the *GRIK5* gene and forms part of the kainate subtype of glutamate-gated ion channels, which mediate excitatory neurotransmission in the central nervous system. GluK5 functions as an auxiliary subunit, modulating the trafficking, kinetics, and ligand sensitivity of the receptor complex when co-assembled with other kainate receptor subunits (e.g., GluK1-GluK4). The N-terminal domain is critical for receptor assembly and interaction with synaptic proteins, making it a key region for studying receptor localization and function.
The GRIK5 (N-term) antibody is commonly used in research applications such as Western blotting, immunohistochemistry, and immunoprecipitation to detect endogenous GluK5 expression. It is particularly valuable in investigating neurological disorders linked to kainate receptor dysfunction, including epilepsy, schizophrenia, and neuropathic pain. Validation of this antibody often involves knockout controls or peptide blocking to confirm specificity. By enabling the study of GluK5’s role in synaptic plasticity and neural circuitry, this tool contributes to understanding the pathophysiology of glutamate signaling imbalances and potential therapeutic targets. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) may vary depending on the commercial source.
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