| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Membrane-associated phosphatidylinositol transfer protein 1, Drosophila retinal degeneration B homolog, Phosphatidylinositol transfer protein, membrane-associated 1, PITPnm 1, Pyk2 N-terminal domain-interacting receptor 2, NIR-2, PITPNM1, DRES9, NIR2, PITPNM |
| Entrez GeneID | 9600 |
| WB Predicted band size | 134.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PITPNM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-171 amino acids from the N-terminal region of human PITPNM1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇涉及PITPNM1(N端)抗体的文献信息及简要摘要：
1. **文献名称**: *PITPNM1 is a key regulator of endoplasmic reticulum-phagosome contact dynamics in macrophages*
**作者**: Du et al. (2021)
**摘要**: 本研究利用针对PITPNM1 N端的特异性抗体，通过免疫荧光染色和免疫共沉淀技术，揭示了PITPNM1在巨噬细胞中调控内质网与吞噬小体接触的关键作用。抗体验证显示其可特异性识别内源性PITPNM1蛋白的N端结构域。
2. **文献名称**: *Lipid transfer protein PITPNM1 modulates chemoresistance through β-catenin nuclear translocation in colorectal cancer*
**作者**: Wang et al. (2019)
**摘要**: 通过Western blot和免疫组化实验(使用PITPNM1 N端抗体)，作者发现PITPNM1在结直肠癌中高表达，并通过β-catenin信号通路增强化疗耐药性。研究证实该抗体在组织样本中具有高特异性。
3. **文献名称**: *Antibody validation and subcellular localization of PITPNM1 isoforms in neuronal cells*
**作者**: Lee & Gomez (2017)
**摘要**: 本文系统验证了多种PITPNM1抗体(包括N端抗体)在神经元细胞中的应用，发现N端抗体可特异性识别PITPNM1主要异构体，并定位其在内质网和高尔基体的分布，为后续功能研究提供工具支持。
注：以上文献为示例性内容，实际引用时需核对真实来源。建议通过PubMed或Web of Science以“PITPNM1 antibody”或“PITPNM1 N-terminal”为关键词检索最新文献，并关注抗体生产商(如CST、Abcam)的技术文档。
The PITPNM1 (N-term) antibody is designed to target the N-terminal region of the phosphatidylinositol transfer protein membrane-associated 1 (PITPNM1), also known as RdgBα or Nir2. PITPNM1 is a conserved protein involved in lipid metabolism and intracellular signaling, particularly in phosphoinositide homeostasis. It plays a critical role in membrane trafficking, cytoskeletal organization, and cellular processes such as secretion, receptor signaling, and cell migration. The N-terminal domain of PITPNM1 contains a phosphatidylinositol transfer protein (PITP) module, essential for lipid transfer between membranes, and interacts with key signaling molecules like PI(4.5)P2 and PI(4)P.
This antibody is commonly used in research to study PITPNM1 expression, localization, and function in various biological contexts, including cancer, neurodegenerative diseases, and metabolic disorders. It is validated for applications such as Western blotting, immunofluorescence, and immunohistochemistry, often aiding in investigations of PITPNM1's role in maintaining endoplasmic reticulum (ER)-plasma membrane contact sites or its association with pathological conditions like metastasis or insulin resistance. Specificity is typically confirmed using knockout controls or siRNA-mediated protein depletion. The antibody's utility extends to both basic research and translational studies exploring PITPNM1 as a potential therapeutic target.
×
