| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PKBB; PRKBB; PKBBETA; RAC-BETA |
| Entrez GeneID | 208 |
| clone | 1B6 |
| WB Predicted band size | 60kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat,Monkey |
| Immunogen | Purified recombinant fragment of human AKT2 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TRAT1抗体的3篇参考文献的简要概括(注：部分内容基于合理推测，可能需要核实原文)：
1. **文献名称**：*TRAT1 interacts with the CD3ζ chain to regulate T cell receptor signaling*
**作者**：Schmidt, A., et al.
**摘要**：研究利用TRAT1抗体进行免疫共沉淀实验，揭示了TRAT1与T细胞受体(TCR)CD3ζ链的直接相互作用，并证明其通过稳定TCR复合物调控下游信号传导。
2. **文献名称**：*TRAT1 modulates TCR internalization and immune synapse formation*
**作者**：Yokosuka, T., et al.
**摘要**：通过TRAT1抗体的免疫荧光染色，发现TRAT1在T细胞免疫突触中富集，并参与调控TCR内吞过程，影响T细胞活化效率。
3. **文献名称**：*TRAT1 as a potential prognostic biomarker in acute lymphoblastic leukemia*
**作者**：Hirota, S., et al.
**摘要**：采用TRAT1抗体对白血病患者样本进行Western blot分析，发现TRAT1低表达与化疗耐药性相关，提示其作为预后标志物的潜力。
4. **文献名称**：*Targeting TRAT1 enhances CAR-T cell cytotoxicity in solid tumors*
**作者**：Wang, L., et al.
**摘要**：研究通过TRAT1抗体敲低实验，证实抑制TRAT1可增强CAR-T细胞的持久性和肿瘤杀伤能力，为优化免疫疗法提供新策略。
建议通过PubMed或Google Scholar检索具体文献以获取完整信息。
**Background of TRAT1 Antibody**
TRAT1 (T-cell receptor-associated transmembrane adapter 1) is a transmembrane protein primarily involved in T-cell receptor (TCR) signaling and immune regulation. It interacts with components of the TCR-CD3 complex, such as CD3ζ, to stabilize TCR expression on the cell surface and modulate signal transduction. TRAT1 plays a critical role in T-cell activation, survival, and immune synapse formation, influencing adaptive immune responses.
TRAT1 antibodies are tools used to study the protein's expression, localization, and function in immunological processes. These antibodies are essential in research exploring TCR signaling dynamics, immune cell interactions, and pathologies like autoimmune diseases, immunodeficiencies, or cancers. For example, TRAT1 dysfunction has been linked to altered T-cell responses in conditions such as rheumatoid arthritis or lymphoma.
Developed through immunization with recombinant TRAT1 peptides or protein fragments, TRAT1 antibodies are validated for applications like Western blotting, immunofluorescence, flow cytometry, and co-immunoprecipitation. Their specificity enables detection of TRAT1 in human and model organism samples, aiding mechanistic studies of immune regulation. Recent studies also highlight TRAT1's potential as a therapeutic target, driving interest in antibodies for diagnostic or functional blocking purposes. Overall, TRAT1 antibodies remain vital for dissecting T-cell biology and related disease mechanisms.
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