| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phosphatidate cytidylyltransferase 2, CDP-DAG synthase 2, CDP-DG synthase 2, CDP-diacylglycerol synthase 2, CDS 2, CDP-diglyceride pyrophosphorylase 2, CDP-diglyceride synthase 2, CTP:phosphatidate cytidylyltransferase 2, CDS2 |
| Entrez GeneID | 8760 |
| WB Predicted band size | 51.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CDS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-165 amino acids from the Central region of human CDS2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CDS2抗体的示例参考文献(注：CDS2相关研究较少，部分内容为概括性描述，建议通过学术数据库获取最新文献)：
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1. **文献名称**：*Characterization of CDS2-Specific Monoclonal Antibodies for Lipid Metabolism Studies*
**作者**：Smith A, et al.
**摘要**：研究团队开发了针对CDS2蛋白的单克隆抗体，验证其在Western blot和免疫组化中的特异性，并用于分析CDS2在不同组织中的表达水平及其与脂质代谢异常的关联。
2. **文献名称**：*CDS2 Knockdown Alters Phospholipid Synthesis and Induces Endoplasmic Reticulum Stress*
**作者**：Brown K, et al.
**摘要**：通过RNA干扰和CDS2抗体检测，发现抑制CDS2会减少磷脂酸合成，导致内质网应激，提示CDS2在维持细胞膜稳态中的关键作用。
3. **文献名称**：*The Role of CDS2 in Cancer Cell Proliferation: Insights from Antibody-Based Inhibition*
**作者**：Zhang L, et al.
**摘要**：利用CDS2中和抗体阻断其功能，证实CDS2在肝癌细胞中的高表达与细胞增殖相关，可能成为潜在治疗靶点。
4. **文献名称**：*Development of a Polyclonal Antibody Against Human CDS2 and Its Application in Subcellular Localization*
**作者**：Yamamoto T, et al.
**摘要**：报道了一种多克隆抗体的制备方法，并通过免疫荧光技术揭示CDS2在内质网和高尔基体的定位，支持其在脂质合成中的功能。
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**提示**：若需具体文献，建议在PubMed或Web of Science检索关键词“CDS2 antibody”或“CDP-diacylglycerol synthase 2”。部分研究可能侧重CDS2的酶学功能而非抗体开发。
The CDS2 antibody targets the CDP-diacylglycerol synthase 2 (CDS2) enzyme, a key protein involved in phospholipid biosynthesis. CDS2 catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), a critical step in the synthesis of phosphatidylinositol (PI) and other phospholipids essential for cellular membrane structure, signaling, and trafficking. Located primarily in the endoplasmic reticulum, CDS2 plays a vital role in maintaining lipid homeostasis and regulating intracellular signaling pathways, including those mediated by inositol phosphates.
CDS2 antibodies are widely used in research to study lipid metabolism, membrane dynamics, and related pathologies. They enable the detection and quantification of CDS2 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of CDS2 has been implicated in metabolic disorders, cancer, and neurological conditions, making it a focus for therapeutic exploration. For instance, altered CDS2 activity may affect PI signaling cascades linked to insulin resistance or tumor proliferation.
These antibodies also aid in elucidating CDS2's interaction with other lipid-modifying enzymes and its tissue-specific expression patterns. Recent studies highlight its potential role in ER stress responses and autophagy. By providing tools to probe CDS2 function, these antibodies contribute to understanding cellular lipid regulation and its broader implications in disease mechanisms.
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