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Rabbit Polyclonal RPAP1(N-term) Antibody

  • 中文名： RPAP1 (N-term)抗体
  • 别    名： RNA polymerase II-associated protein 1, RPAP1, KIAA1403
货号: IPDX31747
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesRNA polymerase II-associated protein 1, RPAP1, KIAA1403
Entrez GeneID26015
WB Predicted band size152.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis RPAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-310 amino acids from the N-terminal region of human RPAP1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于RPAP1 (N-term)抗体的3篇参考文献示例(内容为虚构，仅供参考)：

1. **文献名称**：*"RPAP1 interacts with RNA polymerase II and modulates transcriptional elongation in human cells"*

**作者**：Smith A, et al.

**摘要**：研究通过RPAP1 (N-term)抗体进行免疫共沉淀，发现RPAP1与RNA聚合酶II结合，并参与调控转录延伸过程。实验验证了该抗体在Western blot和ChIP-seq中的特异性。

2. **文献名称**：*"Characterization of the RPAP1 N-terminal domain in the assembly of the HSP90 chaperone complex"*

**作者**：Li X, et al.

**摘要**：利用RPAP1 (N-term)抗体进行免疫荧光和蛋白质互作分析，揭示RPAP1通过N端结构域介导HSP90复合体的组装，影响细胞应激响应。

3. **文献名称**：*"Role of RPAP1 in Cajal body formation and snRNP biogenesis"*

**作者**：Wang Y, et al.

**摘要**：通过RPAP1 (N-term)抗体的敲低和定位实验，证实RPAP1通过N端区域参与Cajal小体形成，调控小核核糖核蛋白(snRNP)的生物合成。

(注：以上文献为模拟内容，实际引用需查询PubMed或学术数据库获取真实文献。)

背景信息

The RPAP1 (N-term) antibody targets the N-terminal region of RNA Polymerase II-Associated Protein 1 (RPAP1), a conserved protein involved in the assembly and regulation of the RNA polymerase II (Pol II) complex. RPAP1 plays a critical role in transcription by facilitating the nuclear import of Pol II subunits and maintaining their stability. It interacts with the RPB1 subunit of Pol II and other chaperone-like proteins, such as HSP90. to ensure proper assembly of the polymerase complex. The N-terminal domain of RPAP1 is essential for its function in cytoplasmic-nuclear shuttling and binding to transcription machinery components. Antibodies specific to the N-terminal region are widely used to study RPAP1's expression, localization, and interactions in cellular processes, including transcriptional regulation, stress responses, and cell cycle progression. They are also employed in research on diseases linked to Pol II dysfunction, such as cancers and neurodegenerative disorders. These antibodies are typically validated in applications like Western blotting, immunoprecipitation, and immunofluorescence, often using models ranging from human tissues to cultured mammalian cells. Host species (e.g., rabbit, mouse) and clonality (polyclonal/monoclonal) may vary depending on the product, but specificity is confirmed through knockout/knockdown controls.

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