| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phosphatidylserine synthase 1, PSS-1, PtdSer synthase 1, Serine-exchange enzyme I, PTDSS1, KIAA0024, PSSA |
| Entrez GeneID | 9791 |
| WB Predicted band size | 55.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PTDSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of human PTDSS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于PTDSS1抗体的参考文献示例(内容为模拟生成，仅供参考)：
1. **文献名称**：*Phosphatidylserine synthase 1 (PTDSS1) regulates tumor progression through lipid metabolism*
**作者**：Zhang Y et al.
**摘要**：研究利用PTDSS1抗体通过Western blot和免疫组化技术，发现PTDSS1在肝癌组织中高表达，并通过调控磷脂代谢促进肿瘤细胞增殖和转移。
2. **文献名称**：*PTDSS1 deficiency alters cellular membrane composition and autophagy in a mouse model*
**作者**：Tanaka K et al.
**摘要**：通过PTDSS1抗体验证基因敲除小鼠模型的蛋白表达缺失，发现PTDSS1缺失导致细胞膜磷脂组成异常，并影响自噬相关通路。
3. **文献名称**：*Role of PTDSS1 in Alzheimer's disease pathogenesis: Insights from post-mortem brain analysis*
**作者**：Smith J et al.
**摘要**：使用PTDSS1抗体对人脑组织进行免疫荧光染色，发现阿尔茨海默病患者脑内PTDSS1表达显著降低，提示其与神经退行性病变的关联。
4. **文献名称**：*PTDSS1 as a potential biomarker for metabolic syndrome: Serum and tissue expression profiling*
**作者**：Lee S et al.
**摘要**：通过ELISA和免疫印迹(使用PTDSS1抗体)分析代谢综合征患者样本，发现血清PTDSS1水平与胰岛素抵抗呈负相关，可能作为疾病标志物。
注：以上文献为示例，实际引用时需根据具体研究检索真实文献(如PubMed、Google Scholar等数据库)。
The PTDSS1 (Phosphatidylserine Synthase 1) antibody is a tool used to detect and study the enzyme phosphatidylserine synthase 1. which plays a critical role in phospholipid metabolism. PTDSS1 catalyzes the conversion of phosphatidylcholine and phosphatidylethanolamine to phosphatidylserine (PS), a key phospholipid involved in cellular membrane structure, signaling, and apoptosis. Dysregulation of PS synthesis has been linked to various pathologies, including cancer, neurodegenerative disorders, and coagulation abnormalities.
Antibodies targeting PTDSS1 are primarily utilized in research to investigate its expression, localization, and function in biological systems. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cell lines, aiding in the exploration of PTDSS1's role in diseases. For instance, elevated PTDSS1 expression has been observed in certain cancers, suggesting its potential as a biomarker or therapeutic target. Conversely, mutations in PTDSS1 are associated with rare genetic disorders like Lenz-Majewski syndrome, characterized by abnormal bone development and craniofacial defects.
These antibodies also contribute to understanding membrane dynamics, apoptosis, and intracellular signaling pathways. Their specificity and validation are crucial for ensuring accurate experimental outcomes, particularly in studies linking phospholipid metabolism to disease mechanisms. Ongoing research continues to uncover PTDSS1's broader implications in cellular homeostasis and pathology.
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