首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal CNDP2 Antibody

  • 中文名： CNDP2抗体
  • 别    名： Cytosolic non-specific dipeptidase, CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2, CN2, CPGL, PEPA
货号: IPDX31744
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCytosolic non-specific dipeptidase, CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2, CN2, CPGL, PEPA
Entrez GeneID55748
WB Predicted band size52.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CNDP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-375 amino acids from the C-terminal region of human CNDP2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于CNDP2抗体的3篇参考文献及其摘要概括：

1. **标题**：CNDP2 overexpression is associated with mitochondrial dysfunction in Alzheimer's disease models

**作者**：Smith A, et al.

**摘要**：研究利用CNDP2抗体检测阿尔茨海默病小鼠模型中CNDP2蛋白表达，发现其过表达与线粒体功能异常相关，可能通过调控氧化应激参与疾病进展。

2. **标题**：Role of CNDP2 in hepatocellular carcinoma progression and its clinical significance

**作者**：Chen L, et al.

**摘要**：通过免疫组化(CNDP2抗体)分析肝癌组织，发现CNDP2高表达与患者预后不良相关，机制涉及促进肿瘤细胞侵袭和转移。

3. **标题**：CNDP2 modulates insulin sensitivity via carnosine metabolism in diabetic mice

**作者**：Wang Y, et al.

**摘要**：研究使用CNDP2抗体检测糖尿病小鼠肌肉组织中蛋白水平，发现CNDP2通过调控肌肽代谢影响胰岛素敏感性，为潜在治疗靶点。

注：上述文献为模拟示例，实际引用需查询具体数据库(如PubMed)获取真实研究。

背景信息

The CNDP2 antibody targets the protein encoded by the *CNDP2* gene (Carnosine Dipeptidase 2), also known as CN2 or CPGL2. This cytoplasmic enzyme, primarily expressed in the liver and kidneys, belongs to the M20 metallopeptidase family and plays a key role in hydrolyzing dipeptides like carnosine and homocarnosine, regulating cellular histidine and β-alanine levels. CNDP2 is implicated in metabolic processes, including antioxidant defense, energy homeostasis, and immune modulation. Dysregulation of CNDP2 has been linked to metabolic disorders (e.g., diabetes), neurological conditions, and cancers, where it may act as either an oncogene or tumor suppressor depending on context. Studies suggest its involvement in tumor metabolism, immune microenvironment modulation, and chemoresistance. CNDP2 antibodies are widely used in research to detect protein expression via techniques like Western blotting, immunohistochemistry, and ELISA, aiding in exploring its biological roles and clinical associations. Recent interest focuses on its potential as a therapeutic target or biomarker, particularly in cancers and age-related diseases. However, its dual roles in different pathologies warrant further mechanistic investigation.

客户数据及评论

折叠内容

大包装询价

×