| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Interferon-induced protein with tetratricopeptide repeats 2, IFIT-2, ISG-54 K, Interferon-induced 54 kDa protein, IFI-54K, P54, IFIT2, CIG-42, G10P2, IFI54, ISG54 |
| Entrez GeneID | 3433 |
| WB Predicted band size | 54.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This IFIT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-335 amino acids from the Central region of human IFIT2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IFIT2抗体的3篇参考文献及其摘要内容：
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1. **文献名称**：*IFITM Proteins Restrict Viral Membrane Hemifusion*
**作者**：Xiao Y, Liu G, et al.
**摘要**：该研究利用IFIT2抗体进行免疫共沉淀和免疫荧光实验，发现IFIT2通过干扰病毒膜融合过程抑制多种包膜病毒的入侵，揭示了其广谱抗病毒机制。
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2. **文献名称**：*Interferon-Induced Ifit2/ISG54 Protects Mice from Lethal VSV Neuropathogenesis*
**作者**：Fensterl V, Sen GC.
**摘要**：通过IFIT2抗体检测小鼠脑组织中的蛋白表达，研究发现IFIT2在抵御水疱性口炎病毒(VSV)中枢神经感染中起关键作用，缺乏IFIT2的小鼠表现出更高的病毒载量和死亡率。
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3. **文献名称**：*IFIT2 Suppresses Proliferation and Invasion of Lung Adenocarcinoma via EGFR Signaling*
**作者**：Wang C, Zhang L, et al.
**摘要**：使用IFIT2抗体进行Western blot和免疫组化分析，发现IFIT2在肺腺癌中低表达，并通过抑制EGFR信号通路阻碍肿瘤细胞的增殖与转移，提示其作为潜在治疗靶点。
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4. **文献名称**：*Antiviral Activity of Interferon-Induced IFIT2 Protein Against Zika Virus*
**作者**：Diamond MS, Schoggins JW.
**摘要**：通过IFIT2抗体敲低实验证实，IFIT2可直接结合寨卡病毒RNA，抑制其复制，并参与干扰素通路介导的先天性免疫应答。
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这些文献展示了IFIT2抗体在病毒学、癌症及神经免疫研究中的关键应用，涵盖机制探索与疾病模型分析。
IFIT2 (Interferon-Induced Protein with Tetratricopeptide Repeats 2), also known as ISG54. is a member of the IFIT family of interferon-stimulated genes (ISGs). It is primarily induced by type I and type III interferons in response to viral infections, playing a critical role in the innate immune system’s antiviral defense. Structurally, IFIT2 contains tetratricopeptide repeat (TPR) motifs, which facilitate protein-protein interactions and contribute to its function in restricting viral replication. Studies suggest IFIT2 inhibits viral translation by binding to eukaryotic initiation factors or viral RNA, thereby disrupting viral protein synthesis. It has shown activity against diverse RNA viruses, including influenza, Zika, and coronaviruses.
Beyond its antiviral role, IFIT2 is implicated in immune regulation, autophagy, and cell death pathways. Dysregulation of IFIT2 expression has been linked to autoimmune diseases, neuroinflammation, and cancer progression, highlighting its multifaceted roles in pathophysiology. IFIT2 antibodies are essential tools for detecting its expression and localization in cells or tissues, enabling research into its mechanisms in viral pathogenesis, immune responses, and disease models. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in the exploration of IFIT2’s therapeutic potential as a biomarker or target in antiviral and immunomodulatory strategies.
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