| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peptidyl-prolyl cis-trans isomerase-like 3, PPIase, Cyclophilin J, CyPJ, Cyclophilin-like protein PPIL3, Rotamase PPIL3, PPIL3 |
| Entrez GeneID | 53938 |
| WB Predicted band size | 18.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PPIL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-146 amino acids from the C-terminal region of human PPIL3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PPIL3(Peptidylprolyl Isomerase Like 3)抗体的模拟参考文献示例(注：以下内容为基于公开知识的模拟生成，非真实文献，建议通过PubMed或Google Scholar查询实际研究)：
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1. **"Characterization of PPIL3-Specific Antibodies for Protein Folding Studies"**
*Authors: Smith A, et al. (2020)*
**摘要**：本研究开发并验证了针对人源PPIL3蛋白的高特异性多克隆抗体，通过免疫印迹和免疫荧光技术证实其在检测细胞中PPIL3表达及定位中的应用，为研究PPIL3在蛋白质折叠中的作用提供工具。
2. **"PPIL3 Modulates Immune Signaling Pathways: Insights from Antibody-Based Inhibition"**
*Authors: Chen L, et al. (2018)*
**摘要**：利用PPIL3特异性单克隆抗体，揭示了PPIL3在T细胞受体信号转导中的调控功能，发现其通过异构酶活性影响下游NF-κB通路，为自身免疫疾病治疗提供潜在靶点。
3. **"A Novel Role of PPIL3 in Cancer Metastasis Revealed by Neutralizing Antibodies"**
*Authors: Gupta R, et al. (2021)*
**摘要**：通过构建PPIL3中和抗体，证实PPIL3在肿瘤细胞侵袭中的作用，并证明抗体干预可抑制乳腺癌细胞迁移，提示PPIL3作为癌症治疗的新生物标志物。
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**提示**：实际研究中，PPIL3相关文献可能较少，建议结合其功能(如肽酰脯氨酰异构酶家族)或疾病关联(如癌症、神经退行性疾病)扩大检索范围。使用关键词“PPIL3 antibody”或“Peptidylprolyl isomerase-like 3”在学术数据库中查询最新进展。
PPIL3 (Peptidylprolyl Isomerase Like 3) is a member of the cyclophilin family of proteins, which are characterized by their peptidyl-prolyl cis-trans isomerase (PPIase) activity. This enzymatic function facilitates protein folding, conformational changes, and interactions by catalyzing the isomerization of peptide bonds involving proline residues. PPIL3. specifically, shares structural homology with other cyclophilins but exhibits distinct expression patterns and potential functional roles. It is encoded by the *PPIL3* gene located on human chromosome 2q14.3 and is expressed in various tissues, with notable levels in immune cells, suggesting a possible link to immune regulation.
Research on PPIL3 remains limited compared to well-studied cyclophilins like cyclophilin A (CypA). However, emerging studies indicate its involvement in mRNA splicing and transcriptional regulation through interactions with spliceosome components or RNA-binding proteins. PPIL3 has also been implicated in cancer progression, with altered expression observed in certain malignancies, though its precise mechanistic role is unclear.
PPIL3 antibodies are primarily used as research tools to detect and quantify PPIL3 protein expression in cellular or tissue samples. They enable investigations into its subcellular localization, interaction partners, and disease associations via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Developing specific and high-affinity PPIL3 antibodies is critical to unraveling its biological functions and potential therapeutic or diagnostic applications, particularly in contexts like cancer or autoimmune disorders where cyclophilin pathways may be dysregulated.
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