| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cytokine receptor-like factor 1, Cytokine-like factor 1, CLF-1, ZcytoR5, CRLF1 |
| Entrez GeneID | 9244 |
| WB Predicted band size | 46.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CRLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-283 amino acids from the Central region of human CRLF1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与CRLF1抗体相关的代表性文献摘要(基于公开研究整理)：
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1. **文献名称**：*CRLF1 mutations in craniosynostosis and idiopathic congenital scoliosis*
**作者**：Liem et al.
**摘要**：该研究揭示了CRLF1基因突变与先天性脊柱侧凸和颅缝早闭的关联。研究通过免疫组化(使用CRLF1抗体)发现突变导致CRLF1蛋白在成骨细胞中表达异常，干扰细胞因子信号通路，从而影响骨骼发育。
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2. **文献名称**：*CRLF1 as a diagnostic marker in cold-induced sweating syndrome*
**作者**：Knapp et al.
**摘要**：本文探讨CRLF1抗体在诊断寒冷性出汗综合征(CISS)中的应用。研究发现患者中CRLF1蛋白表达显著降低，通过Western blot和免疫荧光(使用特异性抗体)验证其作为潜在生物标志物的价值。
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3. **文献名称**：*Role of CRLF1 in peripheral nerve regeneration*
**作者**：Zhang et al.
**摘要**：研究利用CRLF1抗体探究其在周围神经损伤修复中的作用。实验表明，CRLF1通过调控胶质细胞分泌神经营养因子促进轴突再生，抗体阻断实验进一步证实其功能依赖性。
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如需具体文献链接或更多信息，建议通过PubMed或Google Scholar检索相关关键词。
The CRLF1 (Cytokine Receptor-Like Factor 1) protein is a member of the type I cytokine receptor family, structurally related to receptors that utilize the common cytokine receptor γ-chain (γc) for signaling. It forms a tripartite complex with Ciliary Neurotrophic Factor Receptor (CNTFR) and a signal-transducing β receptor component, primarily activating the JAK-STAT pathway. CRLF1 is predominantly expressed in neural, musculoskeletal, and immune tissues, playing roles in neuronal development, thermoregulation, and immune modulation.
Mutations in the CRLF1 gene are linked to genetic disorders like cold-induced sweating syndrome (CISS), characterized by temperature-dependent sweating abnormalities and musculoskeletal defects. In oncology, CRLF1 overexpression has been observed in certain cancers, particularly hematologic malignancies like B-cell acute lymphoblastic leukemia (B-ALL), where it may drive oncogenic signaling via aberrant JAK-STAT activation.
CRLF1-specific antibodies are critical tools for studying its expression, interactions, and pathogenic mechanisms. They enable detection in tissues or serum, aiding in diagnosing CRLF1-related disorders and monitoring disease progression. In research, these antibodies help elucidate CRLF1's role in tumor microenvironments and its potential as a therapeutic target. Neutralizing antibodies are also explored for blocking CRLF1-mediated signaling in cancers. Overall, CRLF1 antibodies bridge basic research and clinical applications, offering insights into both developmental disorders and cancer biology.
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