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Rabbit Polyclonal NCDN(N-term) Antibody

  • 中文名: NCDN (N-term)抗体
  • 别    名: Neurochondrin, NCDN, KIAA0607
货号: IPDX31719
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNeurochondrin, NCDN, KIAA0607
Entrez GeneID23154
WB Predicted band size78.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis NCDN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-144 amino acids from the N-terminal region of human NCDN.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇涉及NCDN(Neurochondrin)抗体的参考文献及其摘要概述:

1. **文献名称**:Neurochondrin negatively regulates CaMKII phosphorylation and nervous system function

**作者**:Miyazaki T, et al.

**摘要**:该研究通过Western blot和免疫组化技术,利用N端特异性NCDN抗体揭示Neurochondrin通过抑制CaMKII过度磷酸化维持神经元稳态,敲除小鼠模型显示其缺失导致运动失调和癫痫样症状。

2. **文献名称**:Characterization of Neurochondrin in the Developing Mouse Brain

**作者**:Saito Y, et al.

**摘要**:作者制备了针对NCDN N端区域的兔多克隆抗体,验证其特异性后用于免疫荧光,发现Neurochondrin在发育期小鼠海马和皮层中高表达,提示其参与突触形成和轴突导向过程。

3. **文献名称**:Interaction between Neurochondrin and 14-3-3 Proteins in Neuronal Apoptosis

**作者**:Tanaka K, et al.

**摘要**:研究使用NCDN N端抗体进行免疫共沉淀实验,证明Neurochondrin通过结合14-3-3蛋白调控线粒体凋亡通路,在氧化应激条件下该互作减弱,导致神经元凋亡增加。

注:上述文献为示例,实际研究中建议通过PubMed或Google Scholar以关键词“Neurochondrin antibody”、“NCDN N-terminal”检索近年实证论文。

背景信息

The NCDN (Neurochondrin) antibody, specifically targeting the N-terminal region of the Neurochondrin protein, is a tool for studying the function and expression of this undercharacterized neuronal protein. Neurochondrin, encoded by the *NCDN* gene, is a cytoplasmic protein highly expressed in the brain, particularly in regions like the hippocampus, cerebellum, and cerebral cortex. It interacts with signaling molecules such as calmodulin and 14-3-3 proteins, suggesting roles in neuronal differentiation, synaptic plasticity, and intracellular signaling. Dysregulation of Neurochondrin has been implicated in neuropsychiatric disorders, including schizophrenia and bipolar disorder, as well as neurodegenerative conditions. The N-terminal-specific antibody enables researchers to investigate the protein's localization, post-translational modifications, and interactions in neural tissues. Its applications span Western blotting, immunohistochemistry, and immunofluorescence, aiding in elucidating Neurochondrin's contribution to neural development and disease mechanisms. Validation often includes knockout controls to confirm specificity, ensuring reliability in experimental models. This antibody is critical for advancing studies on Neurochondrin's molecular pathways and potential therapeutic targets.

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