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Rabbit Polyclonal ATXN7 Antibody

  • 中文名： ATXN7抗体
  • 别    名： Ataxin-7, Spinocerebellar ataxia type 7 protein, ATXN7, SCA7
货号: IPDX31716
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAtaxin-7, Spinocerebellar ataxia type 7 protein, ATXN7, SCA7
Entrez GeneID6314
WB Predicted band size95.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ATXN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-381 amino acids from the Central region of human ATXN7.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ATXN7抗体的3篇参考文献示例(内容为模拟，供参考)：

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1. **文献名称**：*Immunohistochemical analysis of ATXN7 aggregation in spinocerebellar ataxia type 7 mouse models*

**作者**：Smith J, et al.

**摘要**：该研究利用特异性ATXN7抗体，在小鼠模型中揭示了突变ATXN7蛋白在神经元核内形成聚集体的动态过程，证实了聚集体与疾病进展的相关性，并验证了该抗体在组织切片中的高特异性。

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2. **文献名称**：*Development of a polyclonal antibody targeting the N-terminal domain of human ATXN7 for Western blot applications*

**作者**：Chen L, et al.

**摘要**：作者报道了一种新型ATXN7多克隆抗体的开发，通过免疫印迹和免疫沉淀实验验证其对人源ATXN7蛋白N端结构域的特异性识别，为SCA7的分子诊断提供了可靠工具。

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3. **文献名称**：*ATXN7 modulates transcriptional regulation via interaction with STAGA complex: Evidence from antibody-mediated knockdown studies*

**作者**：Garcia-Diaz A, et al.

**摘要**：研究通过ATXN7抗体介导的蛋白功能抑制实验，揭示了ATXN7作为STAGA转录复合物成员在组蛋白乙酰化调控中的作用，为SCA7的病理机制提供了新见解。

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注：以上文献为示例，实际引用需根据具体论文内容调整。建议通过PubMed或Google Scholar以“ATXN7 antibody”为关键词检索最新研究。

背景信息

The ATXN7 antibody is a crucial tool in studying spinocerebellar ataxia type 7 (SCA7), a neurodegenerative disorder caused by a CAG repeat expansion in the ATXN7 gene. This mutation leads to an expanded polyglutamine (polyQ) tract in the ataxin-7 protein, resulting in protein aggregation, neuronal dysfunction, and progressive degeneration of the cerebellum, brainstem, and retina. ATXN7 antibodies are designed to detect either the wild-type or mutant form of the protein, aiding in research on disease mechanisms, protein localization, and expression levels. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze tissue or cell models. Additionally, these antibodies help investigate ATXN7’s role as a component of the SAGA complex, which regulates transcription and chromatin remodeling. Studies using ATXN7 antibodies have revealed insights into how polyQ-expanded ataxin-7 disrupts cellular processes, including proteasomal degradation and gene expression. Commercial ATXN7 antibodies are often validated for specificity using knockout controls or tagged proteins. Their application extends to evaluating therapeutic strategies, such as gene silencing or small molecules targeting mutant ATXN7. However, variability in antibody performance across experimental conditions requires careful validation to ensure reliable data.

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