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Rabbit Polyclonal UBA6 Antibody

  • 中文名: UBA6抗体
  • 别    名: Ubiquitin-like modifier-activating enzyme 6, Ubiquitin-activating enzyme 6, Monocyte protein 4, MOP-4, Ubiquitin-activating enzyme E1-like protein 2, E1-L2, UBA6, MOP4, UBE1L2
货号: IPDX31712
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesUbiquitin-like modifier-activating enzyme 6, Ubiquitin-activating enzyme 6, Monocyte protein 4, MOP-4, Ubiquitin-activating enzyme E1-like protein 2, E1-L2, UBA6, MOP4, UBE1L2
Entrez GeneID55236
WB Predicted band size118.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis UBA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-889 amino acids from the C-terminal region of human UBA6.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于UBA6抗体的参考文献示例(注:以下内容为模拟虚构,仅供参考):

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1. **文献名称**: "UBA6 Regulates Neuronal Development via Ubiquitination of PSD-95"

**作者**: Chen L, et al.

**摘要**: 本研究利用UBA6特异性抗体,通过免疫沉淀和Western blot技术,揭示了UBA6通过泛素化修饰突触后蛋白PSD-95调控神经元突触可塑性的机制。

2. **文献名称**: "Differential Expression of UBA6 in Colorectal Cancer and Its Clinical Implications"

**作者**: Wang Y, et al.

**摘要**: 通过免疫组化及Western blot分析(使用UBA6单克隆抗体),发现UBA6在结直肠癌组织中表达显著下调,且与患者预后不良相关,提示其可能作为抑癌因子发挥作用。

3. **文献名称**: "Functional Redundancy Between UBA6 and UBE1 in Ubiquitin Activation"

**作者**: Smith J, et al.

**摘要**: 本研究通过CRISPR敲除模型结合UBA6抗体检测,证明UBA6与UBE1在泛素激活通路中存在功能冗余,但UBA6特异性参与线粒体蛋白质量控制。

4. **文献名称**: "Characterization of UBA6-Specific Antibodies for Proteomic Studies"

**作者**: Kim H, et al.

**摘要**: 报道了一种高特异性UBA6抗体的开发与验证,通过质谱和免疫荧光证实其可精准识别UBA6.并应用于泛素化修饰组学分析。

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(注:实际文献需通过PubMed/Google Scholar等平台以关键词“UBA6 antibody”或“UBA6 ubiquitin activating enzyme”检索核实。)

背景信息

The UBA6 antibody is a research tool designed to detect and study UBA6 (Ubiquitin-like modifier-activating enzyme 6), a key enzyme in the ubiquitination pathway. UBA6. part of the E1 ubiquitin-activating enzyme family, initiates the cascade of ubiquitin or ubiquitin-like proteins (e.g., FAT10) conjugation to substrate proteins, marking them for degradation via the proteasome or modulating their functional states. Unlike its well-characterized homolog UBA1. UBA6 exhibits distinct substrate specificity and tissue expression patterns, with higher activity in the brain, liver, and testis. Research on UBA6 has linked it to critical cellular processes, including protein homeostasis, cell cycle regulation, and autophagy. Dysregulation of UBA6 is implicated in neurological disorders, cancer, and immune responses. The UBA6 antibody, typically developed in hosts like rabbits or mice using immunogenic peptide regions of the protein, enables techniques such as Western blotting, immunoprecipitation, and immunohistochemistry to investigate UBA6 expression, localization, and interactions. Its specificity and validation in experimental models (e.g., human, mouse) are essential for elucidating UBA6's biological roles and therapeutic potential in disease contexts.

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