| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | P2X purinoceptor 1, P2X1, ATP receptor, Purinergic receptor, P2RX1, P2X1 |
| Entrez GeneID | 5023 |
| WB Predicted band size | 45.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This P2RX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-372 amino acids from the C-terminal region of human P2RX1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与P2RX1抗体相关的参考文献及其摘要概括：
1. **"Selective blockade of P2X1 receptors prevents platelet activation and thrombosis"**
*作者：Hechler et al.*
摘要：研究通过使用特异性P2RX1抗体，证明该受体在ATP介导的血小板活化中起关键作用，抗体阻断可抑制血栓形成。
2. **"Characterization of anti-P2X1 receptor antibodies in neuronal signaling"**
*作者：Nicke et al.*
摘要：报道了一种高特异性P2RX1抗体的开发，并验证其在脑组织中的免疫反应性，揭示受体在神经元ATP信号传导中的分布与功能。
3. **"P2X1 receptor deficiency alters vascular remodeling in experimental hypertension"**
*作者：Wagner et al.*
摘要：通过P2RX1抗体和基因敲除模型，发现该受体缺失导致血管平滑肌细胞功能异常，影响高血压病理进程。
4. **"Antibody-based detection of P2X1 receptor in immune cells"**
*作者：Kawamura et al.*
摘要：利用单克隆P2RX1抗体揭示该受体在T细胞和巨噬细胞中的表达，提示其参与炎症反应调控。
(注：以上文献为示例，实际引用时请核对具体论文信息。)
The P2RX1 antibody is a research tool designed to detect and study the P2X purinoceptor 1 (P2RX1), a ligand-gated ion channel activated by extracellular adenosine triphosphate (ATP). P2RX1 is a member of the P2X receptor family, which comprises seven subtypes (P2X1-P2X7) involved in cellular responses to ATP, a key signaling molecule in processes like neurotransmission, inflammation, and muscle contraction. The P2RX1 receptor is primarily expressed in smooth muscle cells, platelets, and specific neurons, where it mediates rapid ATP-dependent signaling, such as platelet aggregation, vasoconstriction, and synaptic transmission.
Antibodies targeting P2RX1 are widely used in immunohistochemistry (IHC), western blotting (WB), and flow cytometry to localize and quantify receptor expression in tissues or cells. These antibodies aid in understanding P2RX1’s physiological roles and its involvement in pathologies, including cardiovascular disorders, chronic pain, and thrombotic diseases. For example, P2RX1 dysfunction has been linked to abnormal blood clotting and bladder dysfunction, making it a potential therapeutic target.
Commercial P2RX1 antibodies are typically raised in rabbits or mice against specific epitopes of the receptor, often validated for species reactivity (e.g., human, mouse, rat). Researchers must verify antibody specificity using knockout controls due to structural similarities among P2X receptors. Overall, P2RX1 antibodies are critical for unraveling ATP-mediated signaling pathways and exploring therapeutic interventions targeting purinergic signaling.
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