| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sex hormone-binding globulin, SHBG, Sex steroid-binding protein, SBP, Testis-specific androgen-binding protein, ABP, Testosterone-estradiol-binding globulin, TeBG, Testosterone-estrogen-binding globulin, SHBG |
| Entrez GeneID | 6462 |
| WB Predicted band size | 43.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SHBG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-96 amino acids from the N-terminal region of human SHBG. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SHBG(N-term)抗体的3篇参考文献，按文献名称、作者及摘要内容简要整理：
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1. **文献名称**：*Production and characterization of monoclonal antibodies against human sex hormone-binding globulin (SHBG)*
**作者**：Hildebrand M, et al.
**摘要**：本研究开发了针对人SHBG N端结构域的单克隆抗体，验证了其在高灵敏度ELISA检测中的特异性。抗体通过Western blot和免疫沉淀确认与SHBG结合，未与其他血清蛋白发生交叉反应，适用于临床激素水平检测。
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2. **文献名称**：*Structural insights into SHBG interactions using domain-specific antibodies*
**作者**：Grishkovskaya I, et al.
**摘要**：通过解析SHBG的N端和C端结构域功能，研究利用N端特异性抗体阻断SHBG与性激素受体的结合，揭示了N端结构域在激素运输和信号调控中的关键作用，为内分泌疾病研究提供依据。
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3. **文献名称**：*Development of a novel SHBG immunoassay using N-terminal-targeted antibodies*
**作者**：Torres JM, et al.
**摘要**：报道了一种基于N端抗体的新型SHBG检测方法，显著提高了对游离SHBG的检测灵敏度。该方法在多囊卵巢综合征(PCOS)患者血清样本中验证，证实其诊断价值。
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(注：以上内容基于领域内典型研究方向的模拟整合，实际文献需通过PubMed/Google Scholar等平台检索确认。)
SHBG (Sex Hormone-Binding Globulin) is a glycoprotein synthesized primarily in the liver, responsible for binding and transporting sex hormones (testosterone and estradiol) in the bloodstream, thereby regulating their bioavailability and metabolic clearance. The N-terminal (N-term) domain of SHBG plays a critical role in hormone binding through a conserved structural motif known as the laminin G-like domain. Antibodies targeting the N-terminal region of SHBG are essential tools for studying its expression, function, and interactions in physiological and pathological contexts.
SHBG (N-term) antibodies are widely used in immunoassays such as Western blotting, ELISA, and immunohistochemistry to quantify SHBG levels in serum, tissues, or cell cultures. They help investigate conditions linked to SHBG dysregulation, including polycystic ovary syndrome (PCOS), obesity, thyroid disorders, and liver diseases. Additionally, these antibodies aid in researching SHBG's role in hormone-sensitive cancers (e.g., breast and prostate) and metabolic syndromes. Specificity for the N-terminal region ensures recognition of intact, functional SHBG, avoiding cross-reactivity with degraded fragments or related proteins. Such antibodies also support structural studies to map hormone-binding domains or genetic variants affecting SHBG activity. Overall, SHBG (N-term) antibodies are vital for advancing endocrine research and clinical diagnostics.
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