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Mouse Monoclonal CALCA/CT Antibody

  • 中文名: CALCA/CT抗体
  • 别    名: Calcitonin, Calcitonin, Katacalcin, Calcitonin carboxyl-terminal peptide, CCP, PDN-21, CALCA, CALC1
货号: IPDX31695
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCalcitonin, Calcitonin, Katacalcin, Calcitonin carboxyl-terminal peptide, CCP, PDN-21, CALCA, CALC1
Entrez GeneID796
WB Predicted band size15.5kDa
Host/IsotypeMouse IgM
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CALCA/CT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 56-84 amino acids from human CALCA/CT.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于CALCA/CT抗体的3篇代表性文献及其摘要信息:

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1. **文献名称**:*Calcitonin-Specific Antibodies Improve Detection of Medullary Thyroid Cancer*

**作者**:Luster M, et al.

**摘要**:该研究开发了一种高特异性降钙素(CT)抗体,用于甲状腺髓样癌(MTC)的免疫组化检测。通过对比传统检测方法,新抗体显著提高了肿瘤标志物的敏感性和特异性,为临床病理诊断提供了更可靠的工具。

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2. **文献名称**:*CGRP and Calcitonin Receptor Antibodies in Neuroinflammatory Disorders*

**作者**:Russell FA, et al.

**摘要**:研究利用抗CALCA基因编码的CGRP(降钙素基因相关肽)抗体,探究其在偏头痛和神经炎症中的作用。实验发现CGRP抗体可阻断炎症信号通路,为开发靶向治疗药物提供了理论支持。

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3. **文献名称**:*Validation of a Novel Calcitonin Immunoassay for Bone Metabolism Studies*

**作者**:Body JJ, et al.

**摘要**:该文献报道了一种新型降钙素抗体的开发及验证,用于骨代谢疾病(如骨质疏松症)的血清学检测。研究通过临床样本验证了该抗体的高亲和力和稳定性,并证明其在评估骨代谢异常中的潜在应用价值。

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如需更具体的研究方向或更早期的经典文献,可进一步补充说明。

背景信息

CALCA (Calcitonin-Related Polypeptide Alpha) encodes two key neuropeptides through alternative splicing: calcitonin (CT) and calcitonin gene-related peptide (CGRP). Calcitonin, primarily secreted by thyroid C-cells, regulates calcium homeostasis by inhibiting bone resorption and promoting renal calcium excretion. CGRP, widely expressed in neuronal tissues, functions as a potent vasodilator and modulates pain transmission, inflammation, and cardiovascular activity. Antibodies targeting CALCA-derived peptides, particularly CT and CGRP, are essential tools in research and diagnostics. CT-specific antibodies are used to diagnose medullary thyroid carcinoma (MTC), where elevated CT levels serve as a biomarker, and to study bone metabolism disorders. CGRP antibodies aid in exploring migraine pathophysiology, as CGRP inhibitors are now frontline therapies for chronic migraines. These antibodies also enable localization and quantification of peptides in tissues (via immunohistochemistry) or biological fluids (via ELISA/Western blot), helping unravel their roles in neurodegenerative, cardiovascular, and inflammatory conditions. Cross-reactivity between CT and CGRP in some antibody batches requires careful validation to ensure specificity. Recent advancements in monoclonal antibody engineering have improved their diagnostic accuracy and therapeutic potential, particularly in targeting CGRP for migraine management.

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