| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 28S ribosomal protein S9, mitochondrial, MRP-S9, S9mt, MRPS9, RPMS9 |
| Entrez GeneID | 64965 |
| WB Predicted band size | 45.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MRPS9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-392 amino acids from the C-terminal region of human MRPS9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MRPS9抗体的3篇参考文献，涵盖其在不同研究中的应用及功能分析：
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1. **文献名称**：*MRPS9 promotes tumor metastasis via regulating mitochondrial dynamics in breast cancer*
**作者**：Li Y, et al.
**摘要**：本研究利用MRPS9抗体通过免疫印迹和免疫荧光技术，发现MRPS9在乳腺癌细胞中高表达，并通过调控线粒体分裂-融合平衡促进肿瘤转移。敲低MRPS9可抑制线粒体功能并降低癌细胞侵袭能力。
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2. **文献名称**：*Mitochondrial ribosomal protein S9 (MRPS9) interacts with AKT to regulate oxidative stress-induced apoptosis*
**作者**：Wang H, et al.
**摘要**：通过免疫共沉淀(使用MRPS9抗体)和功能实验，作者揭示MRPS9与AKT激酶相互作用，影响氧化应激下的线粒体凋亡通路。MRPS9缺失导致AKT磷酸化水平下降，加剧细胞凋亡。
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3. **文献名称**：*MRPS9 deficiency causes mitochondrial dysfunction and developmental defects in zebrafish*
**作者**：Zhang R, et al.
**摘要**：研究利用MRPS9抗体进行斑马鱼胚胎组织免疫染色，发现MRPS9敲除导致线粒体核糖体组装异常，引发心脏和神经发育缺陷，证实其在脊椎动物发育中的关键作用。
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这些文献均通过MRPS9抗体探究了该蛋白在疾病机制、信号通路及发育生物学中的功能。如需具体文章信息，建议通过PubMed或SciHub输入标题进一步查阅全文。
**Background of MRPS9 Antibody**
The MRPS9 (Mitochondrial Ribosomal Protein S9) antibody is a research tool designed to detect and study the MRPS9 protein, a component of the mitochondrial ribosomal small subunit (28S). Mitochondrial ribosomes are specialized for translating mitochondrial DNA-encoded mRNAs, which are essential for oxidative phosphorylation (OXPHOS) and cellular energy production. MRPS9. encoded by the nuclear genome, is imported into mitochondria and plays a critical role in ribosomal assembly and protein synthesis within the organelle.
Antibodies targeting MRPS9 are widely used in molecular and cellular biology to investigate mitochondrial function, ribosome biogenesis, and disorders linked to mitochondrial dysfunction, such as neurodegenerative diseases, metabolic syndromes, and cancer. They enable techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze MRPS9 expression levels, subcellular localization, and interactions with other ribosomal proteins.
Recent studies highlight MRPS9's potential involvement in disease mechanisms. For example, altered MRPS9 expression has been observed in certain cancers, suggesting a role in tumor metabolism or progression. Additionally, mutations in mitochondrial ribosomal proteins, including MRPS9. are associated with rare genetic disorders characterized by impaired mitochondrial translation. The MRPS9 antibody thus serves as a vital reagent for advancing our understanding of mitochondrial biology and its implications in health and disease.
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