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Rabbit Polyclonal CLCN2(N-term) Antibody

  • 中文名： CLCN2 (N-term)抗体
  • 别    名： Chloride channel protein 2, ClC-2, CLCN2
货号: IPDX31686
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesChloride channel protein 2, ClC-2, CLCN2
Entrez GeneID1181
WB Predicted band size98.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis CLCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-237 amino acids from the N-terminal region of human CLCN2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于CLCN2 (N-terminal)抗体的3篇参考文献示例(基于公开数据及研究方向概括，供参考)：

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1. **文献名称**: *"Characterization of a Novel Antibody Targeting the N-Terminus of Human Chloride Channel CLCN2"*

**作者**: Müller et al.

**摘要**: 本研究报道了一种针对CLCN2蛋白N端结构域的多克隆抗体的开发与验证。通过免疫印迹(Western blot)和免疫组化实验，作者证实该抗体可特异性识别人类和小鼠组织中的CLCN2蛋白，并发现其在神经胶质细胞中高表达，提示CLCN2可能参与维持中枢神经系统的氯离子稳态。

2. **文献名称**: *"CLCN2 Chloride Channel Dysfunction in Epilepsy: Insights from Targeted N-terminal Antibody Staining"*

**作者**: Smith et al.

**摘要**: 利用N端特异性抗体，本研究揭示了CLCN2蛋白在海马神经元中的亚细胞定位异常与癫痫模型小鼠的疾病进展相关。抗体特异性通过CLCN2基因敲除小鼠的阴性实验结果得到验证，支持其在疾病机制研究中的应用价值。

3. **文献名称**: *"Role of CLCN2 in Retinal Function: Immunolocalization Using a Custom N-terminal Antibody"*

**作者**: Zhang et al.

**摘要**: 该文献描述了一种针对CLCN2 N端的定制抗体在视网膜组织中的应用。研究通过免疫荧光技术发现CLCN2在光感受器细胞中的特异性分布，并推测其可能参与视觉信号传导中的离子平衡调节，为视网膜病变的分子机制提供了新线索。

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**注意**：以上文献信息为模拟概括，实际引用时建议通过PubMed或Google Scholar以关键词“CLCN2 antibody N-terminal”检索真实文献，并核对作者及摘要内容。如需具体文献，可提供更详细的研究背景或DOI号进一步查询。

背景信息

The CLCN2 (N-term) antibody is a selective tool used to detect the N-terminal region of the chloride channel protein 2 (ClC-2), encoded by the *CLCN2* gene. ClC-2 belongs to the CLC family of voltage-gated chloride channels and transporters, which play critical roles in maintaining ion homeostasis, cell volume regulation, and membrane potential stabilization. The N-terminal domain of ClC-2 is structurally important, as it contains regulatory motifs influencing channel gating, pH sensitivity, and interactions with cellular proteins. This antibody is commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study ClC-2 expression, localization, and function in various tissues, including the brain, retina, kidneys, and epithelial cells. Research involving CLCN2 (N-term) antibodies has contributed to understanding ClC-2's role in physiological processes such as neuronal excitability, transepithelial transport, and acidification of intracellular organelles. Dysregulation of ClC-2 has been linked to pathologies like leukoencephalopathy, epilepsy, and certain forms of blindness, making this antibody a valuable tool in both basic research and clinical investigations targeting chloride channel-related disorders. Its specificity for the N-terminal region ensures detection of full-length or truncated isoforms, aiding in studies of protein processing or disease-associated mutations.

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