| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Kaptin, Actin-associated protein 2E4, KPTN |
| Entrez GeneID | 11133 |
| WB Predicted band size | 48.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-273 amino acids from the Central region of human KPTN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KPTN抗体的3篇参考文献示例(内容基于公开研究整理，文献标题和作者为虚拟示例)：
1. **文献名称**：*KPTN regulates mTOR signaling and its disruption leads to neurodevelopmental disorders*
**作者**：Smith A, et al.
**摘要**：本研究通过CRISPR筛选和免疫共沉淀(使用KPTN抗体)，发现KPTN蛋白是mTORC1信号通路的关键调控因子，其缺失导致神经元发育异常，与自闭症相关基因突变相关。
2. **文献名称**：*KPTN antibody validation in cancer cell models reveals oncogenic signaling dependencies*
**作者**：Chen L, et al.
**摘要**：作者通过Western blot和免疫荧光(使用特异性KPTN抗体)，验证了KPTN在多种癌细胞系中的高表达，并证明其通过PI3K/AKT通路促进肿瘤生长，为靶向治疗提供依据。
3. **文献名称**：*KPTN interacts with CCDC22 in the endosomal pathway: Implications for intellectual disability*
**作者**：Wang Y, et al.
**摘要**：利用KPTN抗体进行蛋白质组学分析，发现KPTN与CCDC22在内涵体运输中相互作用，其突变破坏溶酶体功能，导致智力障碍相关表型。
**备注**：以上为基于领域知识的模拟文献，实际文献需通过PubMed或Google Scholar检索关键词“KPTN antibody”或“KPTN protein function”获取。建议结合具体研究方向筛选近年高引用论文。
The KPTN antibody targets the protein kaptin (KPTN), encoded by the *KPTN* gene, which is part of the ARM repeat protein family. KPTN plays a critical role in the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, a key regulator of cell growth, metabolism, and autophagy. It interacts with other components of the mTORC1 complex, facilitating its localization to lysosomal membranes, a step essential for nutrient-sensing and pathway activation. Dysregulation of KPTN has been linked to neurodevelopmental disorders, such as epilepsy, intellectual disability, and macrocephaly, often due to loss-of-function mutations.
KPTN antibodies are vital tools for studying these mechanisms, enabling detection of protein expression, subcellular localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. They also aid in exploring KPTN's role in diseases, including its potential as a biomarker or therapeutic target. Research using KPTN antibodies has expanded insights into mTORC1-associated pathologies and cellular homeostasis, bridging gaps between molecular dysfunction and clinical manifestations in genetic disorders.
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