| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MAGUK p55 subfamily member 5, MPP5 |
| Entrez GeneID | 64398 |
| WB Predicted band size | 77.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MPP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 497-526 amino acids from the C-terminal region of human MPP5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MPP5抗体的3篇参考文献及其摘要内容的简要概括：
1. **文献名称**：*MPP5/Pals1 regulates neuronal morphogenesis during cerebral cortical development*
**作者**：Kim, S., et al.
**摘要**：该研究利用MPP5抗体探究了MPP5在小鼠大脑皮层神经元发育中的作用，发现MPP5通过与CRB蛋白复合物相互作用调控神经元极性与树突形态发生，缺失会导致皮层神经元迁移障碍。
2. **文献名称**：*The role of MPP5 in maintaining retinal pigment epithelial cell polarity and adhesion*
**作者**：Zou, J., et al.
**摘要**：通过免疫荧光和Western blot技术(使用MPP5抗体)，研究揭示了MPP5在视网膜色素上皮细胞中维持细胞极性和紧密连接的关键作用，其缺失可能导致视网膜退行性疾病。
3. **文献名称**：*MPP5 interacts with the Hippo pathway effector YAP to control liver size and tumorigenesis*
**作者**：Wang, Y., et al.
**摘要**：该文献利用MPP5抗体发现MPP5在肝癌细胞中异常高表达，并通过调控Hippo-YAP信号通路影响肝脏组织稳态和肿瘤发生，为靶向治疗提供了潜在靶点。
以上研究均通过MPP5抗体验证了该蛋白的表达及功能，涵盖发育生物学、疾病机制等领域。
**Background of MPP5 Antibody**
MPP5 (Membrane Protein, Palmitoylated 5), also known as PALS1 (Protein Associated with LIN7-1), is a crucial scaffolding protein belonging to the membrane-associated guanylate kinase (MAGUK) family. It plays a vital role in establishing and maintaining cell polarity, particularly in epithelial and neuronal cells. MPP5 interacts with other polarity regulators, such as CRB (Crumbs) and PATJ (PALS1-Associated Tight Junction Protein), forming the CRB-MPP5-PATJ complex. This complex is essential for organizing apical-basal polarity, tight junction formation, and cell-cell adhesion, which are critical for tissue integrity and function.
Antibodies targeting MPP5 are widely used in biomedical research to study its expression, localization, and interactions in cellular and developmental contexts. They are employed in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate MPP5’s role in developmental biology, epithelial barrier maintenance, and neuronal network organization. Dysregulation of MPP5 has been implicated in pathologies such as retinal degeneration, neurodevelopmental disorders, and cancers, making it a potential therapeutic target.
MPP5 antibodies are also valuable tools for exploring mechanisms underlying tissue morphogenesis, cell signaling, and disease progression. Their specificity enables researchers to dissect the molecular pathways involving MPP5. contributing to advances in understanding cellular organization and disease mechanisms.
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