| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SLC6A4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GPR174抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *GPR174 is a receptor for CC chemokine ligands and mediates dendritic cell migration to inflammatory sites*
**作者**: Liu C., et al.
**摘要**: 本研究利用特异性GPR174抗体验证了该受体在树突状细胞中的表达，并通过抗体阻断实验发现GPR174通过结合CC类趋化因子(如CCL21)调控树突状细胞的迁移，提示其在炎症反应中的作用。
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2. **文献名称**: *GPR174 deficiency alleviates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cell differentiation*
**作者**: Wang Y., et al.
**摘要**: 通过构建GPR174基因敲除小鼠，并利用抗体验证蛋白表达缺失，研究发现GPR174通过调节T细胞分化影响多发性硬化症模型(EAE)的进展，抗体阻断后Th1/Th17细胞活性显著降低。
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3. **文献名称**: *Development and validation of a monoclonal antibody specific for human GPR174 using CRISPR/Cas9-mediated knockout controls*
**作者**: Zhang R., et al.
**摘要**: 研究团队开发了一种针对人源GPR174的单克隆抗体，通过CRISPR/Cas9敲除细胞系验证其特异性，并证明该抗体适用于流式细胞术和免疫荧光，为后续功能研究提供了可靠工具。
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**备注**：以上文献信息为模拟示例，实际文献需通过PubMed或Web of Science等数据库检索确认。如需具体文献链接，建议使用关键词“GPR174 antibody immune function”进一步筛选。
**Background of GPR174 Antibody**
GPR174. a member of the G protein-coupled receptor (GPCR) family, is implicated in immune regulation and cellular signaling. It is activated by lysophosphatidylserine (lysoPS), a lipid mediator derived from phosphatidylserine, and signals through Gαs proteins to modulate intracellular cAMP levels. GPR174 is highly expressed in immune tissues, particularly in T and B lymphocytes, and plays a role in immune responses, including T-cell migration, thymocyte development, and autoimmune disease pathogenesis.
Antibodies targeting GPR174 are critical tools for studying its expression, localization, and function. They enable detection of GPR174 in various experimental setups, such as Western blotting, immunohistochemistry, and flow cytometry. Research using GPR174 antibodies has revealed its involvement in diseases like autoimmune disorders (e.g., multiple sclerosis) and cancers, where dysregulated GPR174 expression may influence tumor progression or immune evasion.
Recent studies also highlight GPR174's regulatory role in suppressing effector T-cell activity while promoting regulatory T-cell function, suggesting its potential as a therapeutic target. Antibodies against GPR174 aid in elucidating these mechanisms, supporting drug discovery efforts aimed at modulating immune responses or targeting GPCR-related pathologies. Their specificity and reliability are essential for advancing understanding of GPR174's physiological and pathological roles.
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