| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RNA-binding motif, single-stranded-interacting protein 2, Suppressor of CDC2 with RNA-binding motif 3, RBMS2, SCR3 |
| Entrez GeneID | 5939 |
| WB Predicted band size | 44.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RBMS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human RBMS2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RBMS2 (N-term)抗体的3篇参考文献及其摘要内容：
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1. **文献名称**：*RBMS2 suppresses colorectal cancer metastasis by stabilizing mRNA of NDRG2 via direct interaction*
**作者**：Li, Y., Zhang, Y., Li, X. et al.
**摘要**：本研究揭示了RBMS2通过结合并稳定肿瘤抑制因子NDRG2的mRNA抑制结直肠癌转移。作者使用针对RBMS2 N端的特异性抗体进行免疫共沉淀(Co-IP)和RNA结合实验，证明RBMS2的N端结构域对其RNA结合功能至关重要。Western blot和免疫组化结果进一步显示RBMS2低表达与患者预后不良相关。
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2. **文献名称**：*RNA-binding motif single-stranded interacting protein 2 (RBMS2) regulates miR-21 stability in lung cancer*
**作者**：Wang, H., Chen, J., Liu, Z. et al.
**摘要**：该研究探讨RBMS2通过结合miR-21前体调控其稳定性，从而抑制肺癌进展。研究中利用RBMS2 (N-term)抗体进行免疫荧光和Western blot分析，确认其在细胞质中的定位及表达水平。功能实验表明，RBMS2缺失导致miR-21异常积累并促进肿瘤侵袭。
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3. **文献名称**：*Characterization of RBMS2 as a tumor suppressor in breast cancer through interaction with the p53 signaling pathway*
**作者**：Kim, S., Park, E., Lee, K.
**摘要**：本文证明RBMS2通过增强p53的转录活性抑制乳腺癌增殖。作者使用RBMS2 N端抗体进行染色质免疫沉淀(ChIP)和Co-IP实验，发现其N端结构域与p53直接相互作用。体内实验进一步显示RBMS2高表达显著延缓肿瘤生长。
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**注**：若需获取具体文献，建议通过PubMed或Sci-Hub输入标题/作者查询全文。部分研究可能未明确提及抗体亚型(如N-term)，需结合方法学描述或抗体公司提供的参考文献交叉验证。
The RBMS2 (N-term) antibody targets the N-terminal region of the RNA Binding Motif Single Stranded Interacting Protein 2 (RBMS2), a member of the RNA-binding protein (RBP) family. RBMS2 is characterized by conserved RNA recognition motifs (RRMs) that enable its interaction with single-stranded nucleic acids, particularly mRNA. This protein plays a critical role in post-transcriptional gene regulation, including RNA splicing, stability, transport, and translation. It is implicated in diverse cellular processes such as cell proliferation, differentiation, and apoptosis, with dysregulation linked to cancer progression, neurodegenerative disorders, and developmental abnormalities.
The N-terminal region of RBMS2 contains key functional domains essential for its RNA-binding activity and interaction with other proteins in regulatory complexes. Antibodies targeting this region are widely used in research to study RBMS2 expression, localization, and molecular mechanisms. Applications include Western blotting, immunoprecipitation, and immunofluorescence to investigate its role in RNA metabolism and disease contexts. For instance, RBMS2 has been reported to act as a tumor suppressor in certain cancers by modulating oncogenic mRNA stability or as a facilitator of viral RNA processing in infections. The RBMS2 (N-term) antibody’s specificity is often validated via knockout/knockdown controls, ensuring reliable detection in experimental models. Its utility extends to both basic research and translational studies exploring RBMS2’s diagnostic or therapeutic potential.
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