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Rabbit Polyclonal PDS5A Antibody

  • 中文名： PDS5A抗体
  • 别    名： Sister chromatid cohesion protein PDS5 homolog A, Cell proliferation-inducing gene 54 protein, Sister chromatid cohesion protein 112, SCC-112, PDS5A (<a href="http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=29088" target="_bl
货号: IPDX31641
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSister chromatid cohesion protein PDS5 homolog A, Cell proliferation-inducing gene 54 protein, Sister chromatid cohesion protein 112, SCC-112, PDS5A (HGNC:29088)
Entrez GeneID23244
WB Predicted band size150.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PDS5A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1309-1337 amino acids from the C-terminal region of human PDS5A.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PDS5A抗体的3篇参考文献的简要概括(文献信息为模拟示例)：

1. **文献名称**: "PDS5A maintains chromosome cohesion in mitosis and suppresses tumor progression"

**作者**: Zhang et al.

**摘要**: 研究通过PDS5A抗体进行免疫印迹和免疫荧光实验，发现PDS5A通过调控黏连蛋白复合体的稳定性维持染色体正确分离，其表达缺失与多种癌症的基因组不稳定性相关。

2. **文献名称**: "Cohesin subunit PDS5A regulates pluripotency in embryonic stem cells"

**作者**: Li et al.

**摘要**: 利用PDS5A抗体的ChIP-seq技术，揭示了PDS5A通过结合多能性基因启动子区域维持胚胎干细胞的自我更新，并影响染色质三维结构的形成。

3. **文献名称**: "PDS5A dysfunction promotes neurodegeneration in Alzheimer's disease models"

**作者**: Wang et al.

**摘要**: 研究使用PDS5A抗体检测患者脑组织样本，发现PDS5A蛋白水平降低导致神经元染色体断裂和线粒体功能异常，可能与阿尔茨海默病的病理机制相关。

(注：以上文献及作者名为模拟内容，实际引用需以真实数据库检索结果为准。)

背景信息

The PDS5A antibody is a crucial tool in studying the PDS5A protein, a key component of the cohesin complex, which regulates sister chromatid cohesion, DNA repair, and chromatin organization during the cell cycle. PDS5A (Predicted Gene 5A) interacts with other cohesin subunits (e.g., SMC3. RAD21) and modulators (e.g., WAPL) to dynamically control cohesin’s association with chromosomes. It plays dual roles in stabilizing cohesin binding and facilitating its removal, depending on cellular context. Dysregulation of PDS5A is linked to developmental disorders (e.g., Cornelia de Lange-like syndromes) and cancers, including colorectal carcinoma and acute myeloid leukemia, where altered expression correlates with genomic instability and poor prognosis. Researchers use PDS5A antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate its expression, localization, and interactions in normal and diseased states. These antibodies also aid in exploring cohesin’s role in gene regulation, 3D genome architecture, and mitotic fidelity. Commercial PDS5A antibodies are typically raised in rabbits or mice, validated for specificity via knockout controls. Their applications span basic research, biomarker discovery, and therapeutic target validation, emphasizing PDS5A’s emerging significance in cellular homeostasis and disease.

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