| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ribose-phosphate pyrophosphokinase 2, PPRibP, Phosphoribosyl pyrophosphate synthase II, PRS-II, PRPS2 |
| Entrez GeneID | 5634 |
| WB Predicted band size | 34.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PRPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-106 amino acids from the Central region of human PRPS2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PRPS2抗体的3篇假设性参考文献示例，供参考(注：文献为模拟生成，非真实存在)：
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1. **文献名称**: *PRPS2 overexpression in non-small cell lung cancer correlates with chemoresistance*
**作者**: Zhang Y. et al. (2020)
**摘要**: 研究通过免疫组化(使用PRPS2特异性抗体)和Western blot分析，发现PRPS2在非小细胞肺癌组织中显著高表达，且与顺铂化疗耐药性相关。机制研究表明，PRPS2通过调控核苷酸代谢通路影响癌细胞存活。
2. **文献名称**: *PRPS2 knockdown inhibits leukemia cell proliferation via ATP depletion*
**作者**: Li H. et al. (2018)
**摘要**: 利用PRPS2抗体验证shRNA敲低效率，证实PRPS2在急性髓系白血病细胞中的关键作用。研究显示，PRPS2缺失导致细胞内ATP水平下降，从而抑制细胞增殖并诱导凋亡。
3. **文献名称**: *Subcellular localization and functional analysis of PRPS2 in breast cancer*
**作者**: Wang X. et al. (2021)
**摘要**: 通过免疫荧光(使用PRPS2抗体)发现PRPS2主要定位于细胞质，在乳腺癌组织中表达升高。临床数据分析表明，PRPS2高表达与患者不良预后相关，提示其作为潜在生物标志物的价值。
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**备注**：实际研究中，建议通过PubMed、Google Scholar等平台以“PRPS2 antibody”或“PRPS2 + [疾病/功能关键词]”检索真实文献。若需具体文献协助，可提供更详细的研究背景。
**Background of PRPS2 Antibody**
PRPS2 (phosphoribosyl pyrophosphate synthetase 2) is a key enzyme in nucleotide biosynthesis, catalyzing the synthesis of phosphoribosyl pyrophosphate (PRPP), a critical substrate for purine, pyrimidine, and NAD/NADP production. As one of the isoforms in the PRPS family (alongside PRPS1 and PRPS3), PRPS2 is encoded by the *PRPS2* gene and shares functional overlap with PRPS1. though differences in tissue-specific expression and regulatory mechanisms have been noted. Dysregulation of PRPS2 has been implicated in metabolic disorders, cancer progression, and drug resistance, particularly in malignancies like leukemia, hepatocellular carcinoma, and breast cancer, where its overexpression may drive unchecked cell proliferation.
PRPS2-specific antibodies are essential tools for studying the enzyme's expression, localization, and role in disease. These antibodies enable detection and quantification of PRPS2 protein levels in cells or tissues via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They are particularly valuable in cancer research, helping to explore PRPS2's association with tumor aggressiveness, metabolic reprogramming, and therapeutic responses. Additionally, PRPS2 antibodies contribute to understanding genetic disorders linked to nucleotide metabolism defects, such as Arts syndrome (though PRPS1 mutations are more commonly implicated).
Challenges in using PRPS2 antibodies include ensuring specificity due to high homology between PRPS isoforms and optimizing validation protocols. Nonetheless, well-validated PRPS2 antibodies remain crucial for elucidating its biological and pathological roles.
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