| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 60S ribosomal protein L26, RPL26 |
| Entrez GeneID | 6154 |
| WB Predicted band size | 17.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RPL26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-127 amino acids from the C-terminal region of human RPL26. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与RPL26抗体相关的代表性文献摘要(基于公开研究背景虚构，具体文献需核实)：
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1. **文献名称**: "RPL26 modulates p53 translation in response to DNA damage"
**作者**: Zhang Y et al.
**摘要**: 研究发现RPL26通过与p53 mRNA 5'UTR结合，促进DNA损伤后p53的翻译。使用RPL26抗体进行免疫共沉淀实验，证实其与p53 mRNA的相互作用，揭示核糖体蛋白在应激反应中的调控机制。
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2. **文献名称**: "RPL26 is required for hepatitis C virus internal ribosome entry site-mediated translation"
**作者**: Meylan E et al.
**摘要**: 通过RPL26抗体敲低实验，发现RPL26对丙肝病毒(HCV)IRES介导的病毒蛋白翻译至关重要，表明宿主核糖体蛋白在病毒复制中的关键作用，为抗病毒靶点研究提供依据。
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3. **文献名称**: "RPL26 overexpression correlates with poor prognosis in breast cancer"
**作者**: Zhou L et al.
**摘要**: 利用RPL26抗体进行免疫组化分析，发现乳腺癌组织中RPL26表达升高与患者生存率下降显著相关，提示其可能作为肿瘤进展的生物标志物。
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注：以上文献为示例性质，实际引用需根据具体研究检索PubMed等数据库获取真实文献。
**Background of RPL26 Antibody**
RPL26 (Ribosomal Protein L26) is a component of the 60S large ribosomal subunit, playing a critical role in protein synthesis by facilitating ribosome assembly, mRNA binding, and translation regulation. It is encoded by the *RPL26* gene and is highly conserved across eukaryotes. Beyond its canonical ribosomal function, RPL26 has been implicated in stress responses and translational control of specific mRNAs, such as those involved in cell cycle progression and apoptosis. For instance, RPL26 interacts with the p53 mRNA to enhance its translation under DNA damage conditions.
Antibodies targeting RPL26 are widely used in research to study ribosome biogenesis, translational regulation, and cellular stress mechanisms. They are essential tools in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect RPL26 expression, localization, and interactions. Dysregulation of RPL26 has been observed in certain cancers, including colorectal and hepatocellular carcinomas, where its overexpression correlates with tumor progression. Additionally, RPL26 antibodies aid in exploring its role in developmental disorders linked to ribosomal dysfunction (ribosomopathies). Studies also utilize these antibodies to investigate viral infections, as some pathogens exploit ribosomal proteins for replication. Commercial RPL26 antibodies are typically validated for specificity across human, mouse, and rat samples, ensuring broad applicability in biomedical research.
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