| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sialic acid-binding Ig-like lectin 14, Siglec-14, SIGLEC14 |
| Entrez GeneID | 100049587 |
| WB Predicted band size | 44.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SIGLEC14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from the N-terminal region of human SIGLEC14. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SIGLEC14(N-term)抗体的3篇参考文献示例(注：文献为模拟示例，实际引用需核实)：
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1. **文献名称**：*SIGLEC14 regulates neutrophil function in bacterial infection through sialic acid recognition*
**作者**：Wang Y, et al.
**摘要**：本研究利用抗SIGLEC14 N端结构域的单克隆抗体，揭示了SIGLEC14在宿主防御细菌感染中的作用。通过阻断实验发现，该抗体可抑制SIGLEC14与病原体表面唾液酸的结合，从而增强中性粒细胞的杀菌能力。
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2. **文献名称**：*Genetic and functional diversity of SIGLEC14 in primate innate immunity*
**作者**：Angata T, et al.
**摘要**：作者通过SIGLEC14 N-term特异性抗体进行免疫印迹和流式分析，比较了人类与非人类灵长类动物中SIGLEC14的表达差异，并发现其基因多态性可能影响宿主对病原体的免疫应答。
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3. **文献名称**：*SIGLEC14 promotes inflammatory responses in chronic obstructive pulmonary disease*
**作者**：Chen L, et al.
**摘要**：研究使用抗SIGLEC14 N端抗体检测患者肺组织中的蛋白表达，证实SIGLEC14通过激活巨噬细胞NF-κB通路加重炎症，提示其作为COPD潜在治疗靶点。
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**备注**：以上文献为示例性内容，实际研究中可能需要通过PubMed、Google Scholar等平台，以关键词“SIGLEC14 antibody N-terminal”或“SIGLEC14 epitope mapping”检索具体文献。如需实际引用，建议查询抗体生产商(如Abcam、CST)的产品手册引文或相关功能研究论文。
The SIGLEC14 (N-term) antibody is designed to target the N-terminal region of SIGLEC14 (sialic acid-binding immunoglobulin-type lectin 14), a cell surface receptor belonging to the Siglec family. Siglecs are primarily involved in immune modulation through recognition of sialic acid residues on glycoproteins and glycolipids. SIGLEC14. encoded in a genetically polymorphic region of chromosome 19. is expressed on myeloid cells like macrophages and neutrophils. Unlike many inhibitory Siglecs, SIGLEC14 may play a role in activating immune responses, though its exact function remains under investigation.
Notably, the SIGLEC14 gene is closely linked to the pseudogene SIGLEC14P, and certain single nucleotide polymorphisms (SNPs) result in a fusion gene (SIGLEC14/P) with altered ligand-binding properties. This polymorphism has been associated with differential susceptibility to inflammatory diseases, such as chronic obstructive pulmonary disease (COPD) and preterm birth. The N-terminal antibody specifically detects the extracellular domain of SIGLEC14. aiding in studies of its expression, localization, and interaction with pathogens or host ligands.
Researchers use this antibody in techniques like Western blotting, flow cytometry, and immunohistochemistry to explore SIGLEC14's role in immune activation, host-pathogen interactions, and disease mechanisms. Its application contributes to understanding how SIGLEC14 polymorphisms influence immune dysregulation and disease risk.
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