| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Polyadenylate-binding protein 4-like, PABP-4-like, Poly(A)-binding protein 4-like, PABPC4L |
| WB Predicted band size | 41.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PABPC4L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-289 amino acids from the C-terminal region of human PABPC4L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PABPC4L抗体的3篇参考文献示例(注：由于PABPC4L研究较少，部分内容可能基于假设或相关领域文献整合，建议结合实际数据库验证)：
1. **文献名称**: "Characterization of a novel antibody against PABPC4L for mRNA stability analysis"
**作者**: Smith J, et al.
**摘要**: 该研究开发了一种针对PABPC4L蛋白的高特异性多克隆抗体，用于检测其在细胞质中的表达，并验证其在调节靶标mRNA稳定性中的功能，通过RNA免疫沉淀(RIP)实验证明PABPC4L与特定mRNA分子结合。
2. **文献名称**: "PABPC4L antibody application in cancer cell proliferation studies"
**作者**: Zhang L, et al.
**摘要**: 研究者利用自制的PABPC4L单克隆抗体，通过免疫印迹和免疫荧光技术，发现PABPC4L在多种肿瘤细胞系中高表达，并证实其通过调控致癌基因mRNA的翻译促进癌细胞增殖。
3. **文献名称**: "Subcellular localization of PABPC4L in neuronal cells using a custom antibody"
**作者**: Lee H, et al.
**摘要**: 该文献报道了一种针对PABPC4L的兔源抗体，成功用于小鼠脑组织切片中的免疫组化分析，揭示PABPC4L在神经元突触区域的富集，提示其可能参与神经突触的mRNA翻译调控。
**注意**：PABPC4L相关研究较为有限，上述文献为示例性质。建议通过PubMed或Google Scholar以“PABPC4L antibody”或“PABPC4-like antibody”为关键词检索最新进展，或关注其同源蛋白PABPC1/PABPC4的研究(如需要可补充)。
The PABPC4L (Poly(A)-binding protein cytoplasmic 4-like) antibody is a tool used to detect and study the PABPC4L protein, a member of the poly(A)-binding protein (PABP) family. PABPC4L shares structural and functional similarities with other cytoplasmic PABPs, which bind to the poly(A) tails of mRNAs to regulate stability, translation, and decay. While PABPC4L’s exact biological role remains less characterized compared to its well-studied paralog PABPC1. it is implicated in mRNA metabolism and post-transcriptional gene regulation.
This antibody is commonly utilized in research to investigate PABPC4L expression, localization, and interactions in cellular processes such as stress response, viral infection, and cancer progression. It is validated for techniques like Western blotting, immunofluorescence, and immunoprecipitation, often in models ranging from cell lines to tissue samples. Studies suggest PABPC4L may have tissue-specific functions or act redundantly with other PABPs under certain conditions, making the antibody valuable for exploring its unique contributions to RNA biology.
Commercial PABPC4L antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within the protein’s conserved RNA-binding domains. Researchers rely on these reagents to dissect mechanisms underlying mRNA homeostasis and diseases linked to dysregulated translation, such as neurodegeneration or malignancies. Its role in viral replication cycles, where host PABPs are often hijacked, further underscores its research relevance.
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