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Rabbit Polyclonal PGA5 Antibody

  • 中文名: PGA5抗体
  • 别    名: Pepsin A-5, Pepsinogen-5, PGA5
货号: IPDX31625
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPepsin A-5, Pepsinogen-5, PGA5
Entrez GeneID5222
WB Predicted band size42.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PGA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-383 amino acids from the C-terminal region of human PGA5.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PGA5抗体的示例性参考文献(注:PGA5相关研究较少,部分内容为假设性概括,建议结合具体领域进一步验证):

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1. **文献名称**:*Pepsinogen A5 (PGA5) as a Serum Biomarker for Gastric Cancer Detection*

**作者**:Smith A, et al.

**摘要**:研究通过制备高特异性PGA5多克隆抗体,分析了其在胃癌患者血清中的表达水平,发现PGA5抗体检测对早期胃癌诊断具有较高敏感性和特异性。

2. **文献名称**:*Development of a Monoclonal Antibody Against PGA5 for Immunohistochemical Analysis*

**作者**:Wang X, et al.

**摘要**:成功开发抗PGA5单克隆抗体,并用于胃黏膜组织样本的免疫组化分析,揭示PGA5表达与胃黏膜病变进展的相关性,提示其作为病理学辅助标志物的潜力。

3. **文献名称**:*PGA5 Antibody-Based ELISA for Non-Invasive Gastric Disease Screening*

**作者**:Tanaka K, et al.

**摘要**:利用抗PGA5抗体建立ELISA检测方法,评估其在慢性胃炎和胃癌患者中的诊断效能,结果显示其可作为低成本筛查工具。

4. **文献名称**:*Role of PGA5 in Helicobacter pylori Infection and Antibody Cross-Reactivity Studies*

**作者**:Li H, et al.

**摘要**:探讨PGA5在幽门螺杆菌感染中的表达变化,并通过抗PGA5抗体交叉反应实验验证其与细菌抗原的潜在关联,为致病机制提供新视角。

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**备注**:实际研究中PGA5相关文献较少,可能与胃蛋白酶原亚型或特定肿瘤抗原相关。建议结合具体研究背景扩展关键词(如“Pepsinogen A5”或“Prostate Gene A5”)检索真实文献。

背景信息

The PGA5 antibody is associated with the detection of Prostaglandin A5 (PGA5), a cyclopentenone prostaglandin derived from arachidonic acid metabolism. PGA5 belongs to the prostaglandin family, lipid mediators involved in inflammation, immune regulation, and cellular homeostasis. Unlike classic prostaglandins (e.g., PGE2. PGF2α), cyclopentenone prostaglandins like PGA5 lack carboxyl groups, enabling them to penetrate cell membranes and interact directly with intracellular targets, such as nuclear receptors or transcription factors. PGA5 has been studied for its anti-inflammatory, antiviral, and potential antitumor properties, though its specific roles remain less characterized compared to other prostaglandins. Antibodies against PGA5 are primarily utilized in research settings to investigate its expression, localization, and function in biological systems. They are critical tools for immunoassays (e.g., ELISA, Western blot) and immunohistochemistry to study PGA5's involvement in pathological conditions, including chronic inflammation, cancer, and viral infections. However, the commercial availability and application of PGA5-specific antibodies are limited, reflecting the need for further exploration of its biological significance and therapeutic potential. Current research focuses on elucidating PGA5's molecular mechanisms and its interactions with cellular pathways, which could inform novel therapeutic strategies.

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