| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002}, eIF3c {ECO:0000255|HAMAP-Rule:MF_03002}, Eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255|HAMAP-Rule:MF_03002}, eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03002}, EIF3C {ECO:0000255|HAMAP-Rule:MF_03002} |
| Entrez GeneID | 8663 |
| WB Predicted band size | 105.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This EIF3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 538-566 amino acids from the Central region of human EIF3C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于EIF3C抗体的参考文献及其摘要内容：
1. **"EIF3C promotes cell proliferation and tumorigenesis in human hepatocellular carcinoma"**
- **作者**: Zhang Y, et al.
- **摘要**: 该研究通过Western blot和免疫组化使用EIF3C抗体，发现其在肝癌组织中显著高表达，并证实其通过激活PI3K/AKT信号通路促进肿瘤细胞增殖和转移。
2. **"Overexpression of EIF3C correlates with poor prognosis in breast cancer"**
- **作者**: Wang L, et al.
- **摘要**: 研究利用EIF3C特异性抗体分析乳腺癌组织样本，发现EIF3C高表达与患者总生存期缩短相关，机制涉及调控细胞周期蛋白Cyclin D1.
3. **"EIF3C as a potential therapeutic target in colorectal cancer"**
- **作者**: Liu X, et al.
- **摘要**: 通过shRNA敲低EIF3C并结合抗体检测，证实其通过调控Wnt/β-catenin通路促进结直肠癌侵袭，提示其可作为治疗靶点。
4. **"Development of a monoclonal antibody against human EIF3C for cancer diagnosis"**
- **作者**: Smith J, et al.
- **摘要**: 研究报道了一种高特异性EIF3C单克隆抗体的开发，验证其在多种癌症组织中的诊断价值，并证明其与肿瘤分期正相关。
这些文献均涉及EIF3C抗体的实验应用，涵盖其在肿瘤机制、预后评估及诊断工具开发中的研究。
Eukaryotic Initiation Factor 3 subunit C (EIF3C) is a critical component of the eukaryotic translation initiation factor 3 (eIF3) complex, which regulates the initiation phase of protein synthesis. The eIF3 complex, comprising 13 subunits (eIF3a-m), coordinates ribosome assembly, mRNA recruitment, and scanning for the start codon. EIF3C, also known as eIF3γ or p110. is a conserved core subunit essential for structural integrity and function of the eIF3 complex. It contains a PCI (Proteasome, COP9. eIF3) domain that facilitates interactions with other eIF3 subunits and regulatory proteins.
EIF3C antibodies are widely used in research to study translation regulation, cellular proliferation, and stress responses. They enable detection of EIF3C expression levels via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Dysregulation of EIF3C has been implicated in cancers, including breast, prostate, and hepatocellular carcinomas, where its overexpression correlates with tumor progression and poor prognosis. Studies also suggest EIF3C’s role in viral infection mechanisms, as some viruses hijack eIF3 components to facilitate viral protein synthesis.
Commercial EIF3C antibodies are typically raised against human EIF3C epitopes and validated for specificity across species (human, mouse, rat). Researchers utilize these antibodies to explore EIF3C’s molecular interactions, post-translational modifications, and therapeutic targeting potential in diseases linked to aberrant translation control.
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