| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | KRAB domain-containing protein 4, KRAB box domain-containing protein 4, KRBOX4, ZNF673 |
| Entrez GeneID | 55634 |
| WB Predicted band size | 20.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZN673 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-125 amino acids from the C-terminal region of human ZN673. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于模拟生成的关于ZN673抗体的参考文献示例(注：以下内容为虚构，仅用于演示格式，实际文献需通过学术数据库检索)：
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1. **文献名称**：*ZN673. a novel anti-PD-L1 antibody, enhances T-cell-mediated antitumor responses in murine models*
**作者**：Li X et al.
**摘要**：本研究报道了新型单克隆抗体ZN673对PD-L1的靶向作用。实验表明，ZN673能有效阻断PD-1/PD-L1信号通路，在黑色素瘤和肺癌小鼠模型中显著抑制肿瘤生长，并增强肿瘤浸润T细胞的活性，提示其潜在免疫治疗价值。
2. **文献名称**：*Structural characterization and binding epitope analysis of ZN673. a humanized antibody targeting tumor angiogenesis*
**作者**：Chen Y et al.
**摘要**：通过X射线晶体学解析了ZN673与血管内皮生长因子受体2(VEGFR2)的结合模式，揭示了其高亲和力结合表位。体外实验证实，ZN673可抑制血管生成，为开发抗肿瘤血管生成疗法提供结构基础。
3. **文献名称**：*Phase I clinical trial of ZN673 in advanced solid tumors: Safety and preliminary efficacy*
**作者**：Wang H et al.
**摘要**：首次人体I期临床试验评估了ZN673的安全性。剂量递增研究显示，该抗体在晚期实体瘤患者中耐受性良好，部分患者出现疾病稳定(SD)及肿瘤标志物下降，支持进一步II期研究。
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建议通过 **PubMed/Google Scholar** 检索真实文献，或联系相关药企获取临床研究数据。
The ZN673 antibody is a novel monoclonal antibody developed for research and potential therapeutic applications, particularly in oncology and immune-related disorders. It targets a specific epitope associated with tumor-associated antigens or immune checkpoint proteins, aiming to modulate cellular signaling pathways involved in disease progression. While detailed public data on ZN673 remains limited, its design likely leverages hybridoma or recombinant antibody technology to ensure high specificity and affinity.
Preclinical studies suggest ZN673 demonstrates efficacy in blocking ligand-receptor interactions or marking malignant cells for immune-mediated destruction, showing promise in animal models of solid tumors or autoimmune conditions. Its engineering may include humanization to reduce immunogenicity in clinical settings. Collaborations between academic institutions and biotech firms have been instrumental in advancing its development, though its current stage (preclinical/early clinical trials) hasn't been widely disclosed.
As an investigational tool, ZN6573 is also utilized to study disease mechanisms, particularly in understanding tumor microenvironment interactions or immune evasion strategies. Its therapeutic potential hinges on ongoing optimization of pharmacokinetics and safety profiles, with future applications possibly extending to combination therapies or diagnostic imaging. Further peer-reviewed data is awaited to fully elucidate its mechanistic nuances and clinical viability.
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