| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Absent in melanoma 1-like protein, Beta/gamma crystallin domain-containing protein 2, AIM1L, CRYBG2 |
| Entrez GeneID | 55057 |
| WB Predicted band size | 177.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This AIM1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-423 amino acids from the C-terminal region of human AIM1L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AIM1L抗体的3篇参考文献及其摘要概括(注：AIM1L研究相对较少，部分文献可能与功能或应用间接相关)：
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1. **文献名称**: *AIM1L is a novel tumor suppressor in hepatocellular carcinoma*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过免疫组化(使用AIM1L抗体)发现AIM1L在肝癌组织中表达下调，其低表达与患者预后不良相关。体外实验表明AIM1L通过抑制Wnt/β-catenin信号通路抑制肿瘤生长。
2. **文献名称**: *The role of AIM1L in cytoskeletal reorganization and cell migration*
**作者**: Lee S, Kim JH.
**摘要**: 利用AIM1L特异性抗体进行蛋白质定位分析，发现AIM1L通过调控肌动蛋白动态重组影响细胞迁移，提示其在癌症转移中的潜在作用。
3. **文献名称**: *Antibody-based profiling of AIM1L in prostate cancer progression*
**作者**: Gupta R, et al.
**摘要**: 开发了一种高特异性AIM1L单克隆抗体，并用于检测前列腺癌组织中AIM1L的表达水平。结果显示AIM1L表达缺失与肿瘤侵袭性正相关，可能作为预后标志物。
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**说明**：AIM1L(Absent in Melanoma 1-like)相关抗体研究目前较少，以上文献为模拟示例，实际检索建议通过PubMed或Google Scholar结合关键词“AIM1L antibody”或“AIM1L function”获取最新数据。部分研究可能侧重于基因功能而非抗体开发，需注意筛选。
The AIM1L (Absent in Melanoma 1-Like) antibody targets a protein belonging to the βγ-crystallin superfamily, which shares structural homology with AIM1. a tumor suppressor implicated in melanoma progression. AIM1L is encoded by the *AIM1L* gene and is expressed in various tissues, including the brain, testis, and epithelial cells. Though its exact biological role remains under investigation, AIM1L is hypothesized to participate in cytoskeletal organization, cell adhesion, or migration, potentially influencing cancer metastasis and developmental processes.
Structurally, AIM1L contains conserved crystallin domains that may mediate protein-protein interactions or calcium-binding activity. Studies suggest it plays a context-dependent role in tumors; for example, reduced AIM1L expression has been observed in certain cancers, hinting at tumor-suppressive functions. However, its mechanisms differ from AIM1. as AIM1L lacks a coiled-coil domain critical for AIM1's activity. Research also links AIM1L to neurological and immune-related pathways, though these associations require further validation.
AIM1L antibodies are primarily used in research to detect protein expression via techniques like Western blotting, immunohistochemistry, or immunofluorescence. They aid in exploring AIM1L's localization, interaction partners, and dysregulation in diseases. Commercial antibodies are typically validated for specificity, often using recombinant protein or knockout controls. As AIM1L gains attention in cancer biology and cell signaling, its antibody serves as a vital tool for uncovering its physiological and pathological relevance.
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