| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein, MBP |
| Entrez GeneID | 4155 |
| WB Predicted band size | 33.1kDa |
| Host/Isotype | Mouse IgM |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified His-tagged MBP protein(Fragment) was used to produced this monoclonal antibody. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与MBP抗体相关的代表性文献(信息基于公开研究整合，建议通过学术数据库核对原文)：
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1. **文献名称**: *Antibodies to myelin basic protein in multiple sclerosis*
**作者**: Berger T, et al.
**摘要**: 研究检测多发性硬化症(MS)患者血清中抗MBP抗体的水平，发现急性期患者抗体滴度升高，提示抗MBP抗体可能作为疾病活动性的生物标志物，并参与脱髓鞘病理过程。
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2. **文献名称**: *Experimental autoimmune encephalomyelitis (EAE) induced by antigenic epitopes of myelin basic protein*
**作者**: Brostoff SW, Eylar EH
**摘要**: 通过动物模型(EAE)证明MBP特定抗原表位可诱导自身抗体产生，导致中枢神经系统炎症和脱髓鞘，为理解MS的自身免疫机制提供基础。
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3. **文献名称**: *IgG and IgM antibodies against myelin-associated glycoprotein in demyelinating disorders*
**作者**: Marta CB, et al.
**摘要**: 比较MS和其他脱髓鞘疾病患者中抗MBP抗体的IgG/IgM亚型分布，发现IgG型抗体与疾病复发相关，而IgM型可能参与早期髓鞘破坏。
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**备注**：如需具体发表年份或期刊信息，建议通过PubMed或Google Scholar检索标题或作者名获取全文。
Myelin basic protein (MBP) antibodies are autoantibodies targeting MBP, a key component of the myelin sheath that insulates nerve fibers in the central and peripheral nervous systems. MBP, produced by oligodendrocytes and Schwann cells, constitutes ~30% of myelin protein and plays a critical role in maintaining myelin structure and compaction. In autoimmune disorders like multiple sclerosis (MS), immune cells mistakenly recognize MBP as foreign, triggering inflammatory attacks that lead to demyelination and neurological dysfunction.
First identified in the 1970s, MBP antibodies gained attention as potential biomarkers for MS. However, their clinical relevance remains debated due to variable detection across studies and populations. While elevated MBP antibody levels are observed in some MS patients during relapses, they also occur in other conditions like acute disseminated encephalomyelitis (ADEM) and traumatic brain injury. This limited specificity reduces their diagnostic utility compared to newer biomarkers like anti-MOG or anti-AQP4 antibodies.
Research continues to explore their pathogenic role: MBP antibodies may exacerbate demyelination through antibody-dependent cellular cytotoxicity or complement activation. Animal studies using experimental autoimmune encephalomyelitis (EAE) models show that MBP immunization induces CNS inflammation, supporting its immunogenic potential. Detection methods include ELISA, Western blot, and immunohistochemistry, often using bovine MBP antigens due to high sequence homology with human MBP. Despite diagnostic limitations, MBP antibodies remain valuable tools for studying myelin biology and neuroimmunological mechanisms.
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