| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 441, ZNF441 |
| Entrez GeneID | 126068 |
| WB Predicted band size | 80.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF441 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-228 amino acids from the N-terminal region of human ZNF441. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF441(N-term)抗体的假设性参考文献(仅供参考，实际文献需通过学术数据库验证)：
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1. **标题**：*"ZNF441 interacts with chromatin remodelers to regulate gene expression in embryonic stem cells"*
**作者**：Chen et al.
**摘要**：本研究利用ZNF441 N端特异性抗体进行免疫沉淀和ChIP-seq分析，揭示了ZNF441通过N端结构域与染色质重塑复合物相互作用，调控胚胎干细胞多能性相关基因的转录激活。
2. **标题**：*"Development of a polyclonal antibody targeting the N-terminal domain of ZNF441 and its application in cancer biomarker screening"*
**作者**：Kim et al.
**摘要**：报道了一种针对ZNF441 N端的多克隆抗体的制备与验证，通过Western blot和免疫组化证实其在多种癌症组织中高表达，提示ZNF441可能作为潜在肿瘤标志物。
3. **标题**：*"ZNF441 modulates Wnt/β-catenin signaling via direct protein interaction"*
**作者**：Wang et al.
**摘要**：使用ZNF441 N端抗体进行免疫共沉淀实验，发现ZNF441通过N端区域与β-catenin结合，负调控Wnt信号通路，影响结直肠癌细胞的增殖。
4. **标题**：*"Epitope mapping and functional analysis of ZNF441 antibodies in neurological disorders"*
**作者**：Martinez et al.
**摘要**：通过表位定位技术验证了ZNF441 N端抗体的特异性，并应用于阿尔茨海默病模型小鼠脑组织，发现ZNF441表达水平与神经元存活相关。
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**注意**：以上文献为模拟示例，实际研究中可能需结合具体数据库(如PubMed、Google Scholar)以“ZNF441 antibody”“N-terminal epitope”等关键词检索。若公开文献有限，可扩展至ZNF家族其他成员或联系抗体厂商获取技术报告。
The ZNF441 (N-term) antibody is designed to target the N-terminal region of zinc finger protein 441 (ZNF441), a member of the Krüppel-associated box (KRAB)-containing zinc finger protein (ZFP) family. ZNF proteins are characterized by conserved Cys₂-His₂ (C2H2) zinc finger domains, which facilitate sequence-specific DNA binding, enabling their role as transcription regulators. ZNF441 is hypothesized to participate in transcriptional repression or activation by recruiting chromatin-modifying complexes via its KRAB domain, a common feature among KRAB-ZFPs that mediates protein-protein interactions. While the precise biological functions of ZNF441 remain under investigation, it is speculated to contribute to cellular processes such as differentiation, proliferation, or apoptosis, and may be linked to developmental disorders or cancers due to the dysregulation of ZFPs in these contexts.
The ZNF441 (N-term) antibody is commonly used in research applications, including Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP), to detect endogenous ZNF441 protein levels, subcellular localization, or DNA-binding activity. Its specificity for the N-terminal region ensures recognition of full-length or truncated isoforms containing this domain. Validation typically involves knockdown/knout experiments or peptide-blocking assays to confirm target specificity. Researchers utilize this antibody to explore ZNF441's role in gene regulatory networks, its interaction partners, and its potential implications in disease mechanisms. Commercial variants may differ in host species (e.g., rabbit, mouse) and conjugation formats (e.g., unlabeled, HRP-conjugated), tailored for specific experimental workflows.
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