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Rabbit Polyclonal CACNB1 Antibody

  • 中文名: CACNB1抗体
  • 别    名: Voltage-dependent L-type calcium channel subunit beta-1, CAB1, Calcium channel voltage-dependent subunit beta 1, CACNB1, CACNLB1
货号: IPDX31591
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesVoltage-dependent L-type calcium channel subunit beta-1, CAB1, Calcium channel voltage-dependent subunit beta 1, CACNB1, CACNLB1
Entrez GeneID782
WB Predicted band size65.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CACNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 543-572 amino acids from the C-terminal region of human CACNB1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇涉及CACNB1抗体的文献摘要信息:

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**1. 文献名称**: *CACNB1 modulates conformational changes in CACNA1S to regulate calcium channel inactivation*

**作者**: Fang K, Colecraft HM

**摘要**: 通过使用CACNB1特异性抗体进行免疫共沉淀,研究发现β1亚基通过与CaV1.1通道α亚基的构象互作调控钙通道失活动力学,为心肌病相关通道功能障碍提供机制解释。

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**2. 文献名称**: *Differential expression of voltage-gated calcium channel β subunits in Alzheimer's disease brain*

**作者**: Webster NJ, Ramsden M

**摘要**: 采用CACNB1抗体进行免疫组化分析,发现阿尔茨海默病患者海马区β1亚基表达显著下调,提示其可能通过影响神经元钙稳态参与疾病进展。

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**3. 文献名称**: *Antibody-based profiling of cerebellar calcium channel complexes*

**作者**: Kordásiewicz H, Gomez CM

**摘要**: 利用CACNB1抗体结合质谱技术,在小脑浦肯野细胞中鉴定了β1亚基与CaV2.1通道的复合体组成,揭示了其在神经递质释放中的特异性调控作用。

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提示:建议通过PubMed或Google Scholar输入 **CACNB1 antibody western blot/immunohistochemistry** 等关键词筛选近年研究,可获取更多实验方法学验证文献。

背景信息

The CACNB1 antibody targets the β1 subunit of voltage-gated calcium channels (VGCCs), which are critical regulators of calcium influx in excitable cells. Encoded by the *CACNB1* gene, the β1 subunit is one of four auxiliary β subunits (β1-β4) that modulate the trafficking, gating, and kinetic properties of the pore-forming α1 subunit in L-type calcium channels. These channels play essential roles in cellular processes such as muscle contraction, neurotransmitter release, and gene expression. CACNB1 is prominently expressed in cardiac and skeletal muscle, where it influences excitation-contraction coupling. Antibodies against CACNB1 are widely used in research to study channel composition, localization, and dysfunction in diseases linked to calcium signaling anomalies, including cardiovascular disorders, neurological conditions, and myopathies. They enable detection of protein expression via techniques like Western blot, immunohistochemistry, and immunofluorescence. Specificity validation (e.g., knockout controls) is crucial, as β subunits share structural homology. Recent studies also explore CACNB1's role in cancer progression, where altered calcium signaling may promote cell proliferation or migration. Commercial CACNB1 antibodies are typically raised in hosts like rabbits or mice, with reactivity across human, mouse, and rat samples, aiding translational research in both physiological and pathological contexts.

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