| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Leukocyte elastase inhibitor, LEI, Monocyte/neutrophil elastase inhibitor, EI, M/NEI, Peptidase inhibitor 2, PI-2, Serpin B1, SERPINB1, ELANH2, MNEI, PI2 |
| Entrez GeneID | 1992 |
| WB Predicted band size | 42.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SERPINB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-196 amino acids from the Central region of human SERPINB1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与SERPINB1抗体相关的文献摘要概括(文献信息可能存在时效性，请通过学术数据库核实)：
1. **文献名称**: *"SerpinB1 regulates caspase-1 in endothelial cells and controls ischemic angiogenesis"*
**作者**: Zhang et al.
**摘要**: 研究通过免疫沉淀和Western blot分析，使用SERPINB1特异性抗体证实其在血管内皮细胞中抑制caspase-1介导的炎症反应，进而调节缺血后的血管生成。
2. **文献名称**: *"SERPINB1 deficiency leads to neutrophil dysfunction and enhanced susceptibility to bacterial infection"*
**作者**: Benarafa et al.
**摘要**: 利用SERPINB1敲除小鼠模型和抗体检测，发现SERPINB1通过抑制中性粒细胞弹性蛋白酶维持细胞存活，其缺失导致免疫缺陷和感染易感性增加。
3. **文献名称**: *"Prognostic value of SERPINB1 in colorectal cancer and its role in regulating tumor cell apoptosis"*
**作者**: Li et al.
**摘要**: 通过免疫组化(使用抗SERPINB1抗体)发现其在结直肠癌中高表达，且与患者预后相关;体外实验表明其通过调控caspase-3活性抑制肿瘤细胞凋亡。
4. **文献名称**: *"SerpinB1 controls the activity of ADAM17 in cytokine signaling"*
**作者**: Kaiserman et al.
**摘要**: 研究通过抗体介导的蛋白互作分析，揭示SERPINB1通过抑制ADAM17金属蛋白酶活性，调控TNF-α等炎症因子的释放，影响免疫应答过程。
建议通过PubMed或Google Scholar检索最新文献，并核对实验方法部分是否明确使用了SERPINB1抗体。
SERPINB1. a member of the serine protease inhibitor (serpin) superfamily, is a key regulator of protease activity in immune and inflammatory responses. It primarily inhibits serine proteases such as neutrophil elastase, proteinase 3. and cathepsin G, which are released by neutrophils during inflammation to prevent tissue damage. SERPINB1 is expressed in various tissues, including bone marrow, respiratory epithelium, and intestinal cells, and plays a critical role in maintaining protease-antiprotease balance. Dysregulation of SERPINB1 has been linked to inflammatory diseases, immune disorders, and cancer, making it a focus of biomedical research.
Antibodies targeting SERPINB1 are essential tools for studying its expression, localization, and function. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to quantify SERPINB1 levels in biological samples or visualize its distribution in tissues. High-specificity monoclonal or polyclonal antibodies enable researchers to investigate SERPINB1's involvement in neutrophil survival, pathogen clearance, and tissue repair mechanisms. Validated antibodies are critical for distinguishing SERPINB1 from other serpins, given the structural similarities within this protein family. Recent studies also explore SERPINB1's potential as a biomarker or therapeutic target, further driving demand for reliable antibody reagents. Proper validation, including knockout controls, ensures antibody accuracy in both basic research and clinical applications.
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