| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nuclear migration protein nudC, Nuclear distribution protein C homolog, NUDC |
| Entrez GeneID | 10726 |
| WB Predicted band size | 38.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NUDC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-133 amino acids from the Central region of human NUDC. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NUDC抗体的3篇代表性文献示例，涵盖不同研究方向：
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1. **文献名称**：*NUDC调控肿瘤细胞有丝分裂的机制研究及其抗体应用*
**作者**：Liu Y, Wang X, Zhang H.
**摘要**：本研究通过构建NUDC特异性抗体，验证其在多种肿瘤细胞系中的表达水平。实验表明，NUDC通过稳定微管蛋白参与有丝分裂，其抗体可抑制肿瘤细胞增殖并诱导凋亡，提示其作为癌症治疗靶点的潜力。
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2. **文献名称**：*NUDC在神经元迁移中的功能及抗体定位分析*
**作者**：Tanaka K, Suzuki T, Nakayama J.
**摘要**：利用NUDC多克隆抗体进行免疫荧光染色，发现NUDC在小鼠大脑皮层神经元迁移中关键作用。抗体特异性验证显示，NUDC缺失导致神经元定位异常，支持其在神经发育中的功能。
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3. **文献名称**：*基于CRISPR的NUDC抗体验证及其在病毒感染研究中的应用*
**作者**：Chen L, Zhou M, Li J.
**摘要**：开发并验证了高特异性NUDC单克隆抗体，结合CRISPR敲除技术证明NUDC与特定病毒蛋白互作。抗体阻断实验显示，NUDC是病毒复制必需宿主因子，为抗病毒治疗提供新思路。
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**注**：上述文献为示例，实际研究中请通过PubMed、Google Scholar等平台检索最新论文。真实研究多聚焦于NUDC在细胞分裂、癌症及神经疾病中的机制，抗体常被用于蛋白互作、表达定位及功能抑制实验。
NUDC (Nuclear Distribution Protein C) is a conserved protein involved in regulating mitotic processes, particularly spindle assembly and chromosome segregation during cell division. It interacts with components of the dynein-dynactin complex and the LIS1/NDEL1 pathway, playing a critical role in nuclear migration, neuronal development, and microtubule dynamics. Dysregulation of NUDC is linked to developmental defects, neurodegenerative disorders, and cancer progression due to its influence on cell cycle control and genomic stability.
NUDC antibodies are essential tools for studying its expression, localization, and functional mechanisms. They enable detection via techniques like Western blot, immunofluorescence, and immunohistochemistry, aiding research on NUDC's role in diseases. For example, elevated NUDC levels correlate with poor prognosis in certain cancers, making it a potential therapeutic target. In neurobiology, these antibodies help explore NUDC's involvement in corticogenesis and axon guidance. Commercial NUDC antibodies are typically raised against specific epitopes, with validation in model organisms underscoring their cross-species relevance. Ongoing studies focus on clarifying NUDC's pleiotropic functions and its crosstalk with signaling pathways, highlighting its broader implications in cellular homeostasis and disease pathology.
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