| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nuclear receptor subfamily 4 group A member 3, Mitogen-induced nuclear orphan receptor, Neuron-derived orphan receptor 1, Nuclear hormone receptor NOR-1, NR4A3, CHN, CSMF, MINOR, NOR1, TEC |
| Entrez GeneID | 8013 |
| WB Predicted band size | 68.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NR4A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human NR4A3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与NR4A3抗体相关的典型文献摘要(文献标题与作者为虚构示例，仅供格式参考)：
1. **《NR4A3在头颈部腺样囊性癌中的诊断价值》**
- 作者：Smith J et al.
- 摘要：通过免疫组化验证NR4A3抗体的特异性，发现其在腺样囊性癌中高表达，可作为与其它唾液腺肿瘤的鉴别诊断标志物。
2. **《NR4A3缺失通过调控脂肪代谢促进脂肪肉瘤发生》**
- 作者：Li X et al.
- 摘要：采用Western blot和免疫荧光技术，证实NR4A3抗体在脂肪肉瘤组织中表达缺失，其下调可能通过PPARγ通路驱动肿瘤进展。
3. **《新型NR4A3单克隆抗体在小鼠模型中的抗炎作用研究》**
- 作者：Wang Y et al.
- 摘要：开发高亲和力NR4A3单克隆抗体，证明其可通过抑制NF-κB通路减轻类风湿性关节炎模型小鼠的炎症反应。
注：实际文献需通过PubMed/Google Scholar检索关键词"NR4A3 antibody"+"IHC/WB"等获取，建议结合具体研究场景筛选。
The NR4A3 antibody is a crucial tool for studying the nuclear receptor subfamily 4 group A member 3 (NR4A3), a transcription factor involved in cellular processes like differentiation, proliferation, and apoptosis. NR4A3. also known as NOR-1 or MINOR, is part of the NR4A family, which includes ligand-independent orphan receptors. It contains a DNA-binding domain (DBD) and a ligand-binding domain (LBD), enabling its role in regulating target gene expression. NR4A3 is expressed in various tissues and is implicated in metabolic regulation, inflammation, and cancer.
Antibodies targeting NR4A3 are used in techniques such as Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression, localization, and dynamics. These antibodies are typically raised in hosts like rabbits or mice, with validated specificity through knockout (KO) controls or peptide blocking. They help elucidate NR4A3's role in diseases, including pancreatic acinar cell carcinoma (where NR4A3 fusion genes drive oncogenesis) and acute myeloid leukemia (AML), where its dysregulation affects cell survival.
Commercial NR4A3 antibodies are available from suppliers like CST, Abcam, and Santa Cruz Biotechnology. Researchers rely on these reagents to explore NR4A3’s interactions with co-regulators, response elements, and signaling pathways (e.g., cAMP/PKA). Proper validation ensures minimal cross-reactivity with homologous family members (NR4A1/Nur77. NR4A2/Nurr1), critical for accurate experimental outcomes in both basic and translational studies.
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