| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein ZFPM2, Friend of GATA protein 2, FOG-2, Friend of GATA 2, hFOG-2, Zinc finger protein 89B, Zinc finger protein multitype 2, ZFPM2, FOG2, ZNF89B |
| Entrez GeneID | 23414 |
| WB Predicted band size | 128.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZFPM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 883-911 amino acids from the C-terminal region of human ZFPM2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZFPM2抗体的3篇参考文献示例(注：部分信息为模拟示例，实际引用时请核实原文)：
1. **文献名称**: "ZFPM2/FOG2 regulates endothelial differentiation and hematopoiesis through the NOTCH pathway"
**作者**: Sánchez-Castillo M, et al.
**摘要**: 本研究利用ZFPM2特异性抗体通过ChIP-seq和免疫荧光技术，揭示了ZFPM2在血管内皮细胞分化中通过调控NOTCH信号通路影响造血干细胞发育的分子机制。
2. **文献名称**: "Loss of ZFPM2/FOG2 in hepatocellular carcinoma correlates with EMT activation"
**作者**: Li Y, Wang X, Zhang H.
**摘要**: 通过免疫组化(使用兔源抗ZFPM2单克隆抗体)分析肝癌组织，发现ZFPM2表达缺失与上皮间质转化(EMT)显著相关，提示其作为肿瘤抑制因子的潜在作用。
3. **文献名称**: "Antibody-based profiling of ZFPM2 isoforms in human cardiomyocytes"
**作者**: Gupta R, et al.
**摘要**: 开发了针对不同ZFPM2异构体的特异性抗体，验证了其在心肌细胞中的差异化表达模式，为先天性心脏病研究提供了新工具。
**备注**：实际文献需通过PubMed或Web of Science等平台以关键词"ZFPM2 antibody"、"FOG2 antibody"检索获取，建议优先选择近5年发表于《Development》《Oncogene》等期刊的研究。
The ZFPM2 antibody is designed to detect Zinc Finger Protein, FOG Family Member 2 (ZFPM2), also known as Friend of GATA-2 (FOG-2). ZFPM2 is a transcriptional regulator that interacts with GATA-binding proteins (e.g., GATA4. GATA6) to modulate gene expression critical for embryonic development, particularly in cardiac and reproductive systems. It plays essential roles in heart morphogenesis, neural development, and gonadal differentiation by either enhancing or repressing GATA-dependent transcription.
ZFPM2 antibodies are widely used in research to study protein expression, localization, and function in tissues or cell lines. Applications include Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Dysregulation of ZFPM2 is linked to congenital heart defects (e.g., tetralogy of Fallot), neurodevelopmental disorders, and reproductive abnormalities. In cancer, altered ZFPM2 expression has been observed in leukemia and certain solid tumors, suggesting potential roles in oncogenesis or tumor suppression.
These antibodies are typically raised in rabbits or mice, targeting specific epitopes within ZFPM2's conserved zinc finger domains. Validation often involves knockout controls or siRNA-mediated knockdown to confirm specificity. As a tool, ZFPM2 antibodies aid in elucidating molecular pathways in development and disease, offering insights for therapeutic targeting or diagnostic biomarker discovery.
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