| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Pre-B-cell leukemia transcription factor 2, Homeobox protein PBX2, Protein G17, PBX2, G17 |
| Entrez GeneID | 5089 |
| WB Predicted band size | 45.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This PBX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-210 amino acids from the Central region of human PBX2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PBX2抗体的示例参考文献(注：以下内容为假设性示例，仅供参考)：
1. **文献名称**：*PBX2 regulates early hematopoietic progenitors via transcriptional control of HOX gene expression*
**作者**：Moens, C.B., Selleri, L.
**摘要**：本研究利用PBX2特异性抗体进行染色质免疫沉淀(ChIP)和免疫组化实验，发现PBX2与HOX蛋白协同调控造血干细胞的分化，揭示了其在早期胚胎发育中的关键作用。
2. **文献名称**：*The role of PBX2 in prostate cancer progression and its diagnostic utility*
**作者**：Svingen, T., et al.
**摘要**：通过PBX2抗体检测前列腺癌组织样本，发现PBX2蛋白高表达与肿瘤侵袭性相关，提示其可能作为潜在生物标志物。
3. **文献名称**：*PBX2 antibody validation for chromatin immunoprecipitation sequencing (ChIP-seq) in human fibroblasts*
**作者**：Dard, A., et al.
**摘要**：该研究系统验证了PBX2抗体的特异性，成功应用于ChIP-seq分析，揭示了PBX2在成纤维细胞中对细胞外基质基因的调控机制。
4. **文献名称**：*PBX2 modulates Wnt/β-catenin signaling in colorectal cancer*
**作者**：Kim, M., et al.
**摘要**：使用PBX2抗体进行Western blot和免疫荧光实验，证明PBX2通过调控Wnt通路靶基因促进结直肠癌细胞增殖。
建议通过PubMed或Google Scholar以“PBX2 antibody”或“PBX2 immunohistochemistry”等关键词检索真实文献。
**Background of PBX2 Antibody**
The PBX2 (Pre-B-cell leukemia homeobox 2) antibody is a tool used to detect and study the PBX2 protein, a member of the TALE (Three-Amino-acid Loop Extension) family of homeodomain transcription factors. PBX2. along with PBX1. PBX3. and PBX4. plays critical roles in embryonic development, cellular differentiation, and tissue homeostasis by regulating gene expression. It functions as a transcriptional co-factor, often partnering with HOX proteins to modulate their DNA-binding specificity and activity, thereby influencing processes like organogenesis, skeletal patterning, and hematopoiesis.
PBX2 is ubiquitously expressed in various tissues, with notable roles in neural, cardiac, and immune system development. Dysregulation of PBX2 has been linked to cancers, including leukemias and solid tumors, where it may act as an oncogene or tumor suppressor depending on context.
Antibodies targeting PBX2 are essential for investigating its expression, localization, and interactions in both normal and pathological states. These antibodies are validated for techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Specificity is ensured through knockout controls or peptide-blocking assays. Research using PBX2 antibodies contributes to understanding developmental biology, disease mechanisms, and potential therapeutic targets.
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