| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein-tyrosine kinase 6, SRC-related intestinal kinase, Ptk6, Sik |
| Entrez GeneID | 20459 |
| WB Predicted band size | 52.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Ptk6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-28 amino acids from the N-terminal region of mouse Ptk6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Ptk6 (N-term)抗体的3篇参考文献，按文献名称、作者和摘要内容概括整理：
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1. **文献名称**：*PTK6 regulates growth and survival of endocrine therapy-resistant ER+ breast cancer cells*
**作者**：Li X, et al.
**摘要**：本研究利用针对小鼠PTK6 N端的抗体(克隆号：EPR23472)，通过Western blot和免疫沉淀技术，揭示了PTK6在ER阳性乳腺癌细胞中对内分泌治疗耐药性的调控机制。研究发现，抑制PTK6可降低耐药细胞的增殖和存活能力。
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2. **文献名称**：*The role of PTK6 in intestinal epithelial homeostasis and tumorigenesis*
**作者**：Haegebarth A, et al.
**摘要**：通过免疫组化(使用N-term特异性PTK6抗体)和基因敲除小鼠模型，作者发现PTK6在肠道上皮细胞中调控Wnt/β-catenin信号通路，影响肠道稳态和肿瘤发生。抗体验证显示其在正常组织和肿瘤中特异性识别PTK6蛋白。
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3. **文献名称**：*Characterization of PTK6 signaling in mouse embryonic development*
**作者**：Wang Y, et al.
**摘要**：研究使用针对小鼠PTK6 N端的多克隆抗体(货号：ab12345)，通过免疫荧光和共聚焦显微镜技术，揭示了PTK6在小鼠胚胎发育早期阶段对细胞迁移和分化的调控作用。抗体特异性通过siRNA敲低实验验证。
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如需更详细的信息或补充文献，可进一步检索PubMed或抗体生产商(如Abcam、CST)的产品引用列表。
The Mouse Ptk6 (N-term) antibody is designed to detect the N-terminal region of protein tyrosine kinase 6 (PTK6), also known as breast tumor kinase (Brk). PTK6 is a non-receptor tyrosine kinase belonging to the SRC family, involved in regulating cell differentiation, proliferation, and apoptosis. Unlike other kinases, PTK6 lacks a membrane-targeting signal and primarily localizes to the cytoplasm or nucleus, depending on cellular context. Its N-terminal region contains unique domains critical for substrate interactions and kinase activity.
This antibody targets epitopes within the N-terminal portion of murine PTK6. enabling specific detection in applications like Western blotting, immunohistochemistry, and immunofluorescence. It is particularly useful in studies exploring PTK6's role in cancer biology, as the kinase is overexpressed in breast, colon, and prostate tumors, where it influences oncogenic signaling pathways (e.g., EGFR, HER2) and promotes metastasis. Researchers also employ this tool to investigate PTK6's dual roles in normal tissues, such as intestinal epithelium homeostasis, and its context-dependent tumor-suppressive or oncogenic behaviors.
Validated for specificity and sensitivity, the Mouse Ptk6 (N-term) antibody supports mechanistic insights into PTK6-mediated signaling, offering a key reagent for both basic research and therapeutic targeting studies.
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