| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Plakophilin-3, PKP3 |
| Entrez GeneID | 11187 |
| WB Predicted band size | 87.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PKP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 766-794 amino acids from the C-terminal region of human PKP3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于PKP3抗体的参考文献示例(注：部分文献信息为模拟示例，实际引用时请核实原文)：
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1. **文献名称**: *Plakophilin 3 (PKP3) as a biomarker in squamous cell carcinoma*
**作者**: Schmidt A, et al.
**摘要**: 该研究通过免疫组化(IHC)和Western blotting技术，使用PKP3特异性抗体分析了其在口腔鳞状细胞癌中的表达。结果显示，PKP3在肿瘤组织中的表达显著下调，且与淋巴结转移和患者预后不良相关，提示其作为潜在诊断标志物的价值。
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2. **文献名称**: *Role of PKP3 in desmosomal adhesion and epidermal integrity*
**作者**: Bass-Zubek AE, et al.
**摘要**: 本研究利用PKP3抗体探究了该蛋白在桥粒结构和表皮细胞粘附中的作用。通过基因敲除模型和免疫荧光技术，发现PKP3缺失导致细胞间连接稳定性下降，揭示了其在维持皮肤屏障功能中的关键机制。
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3. **文献名称**: *PKP3 expression in cutaneous diseases: Insights from antibody-based profiling*
**作者**: Hofmann I, et al.
**摘要**: 通过组织微阵列和PKP3抗体进行免疫组化分析，发现PKP3在银屑病和皮肤癌中的异常表达模式。研究提示PKP3可能参与炎症性皮肤病的病理过程，并为靶向治疗提供新方向。
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**备注**：若需实际文献，建议通过PubMed或Google Scholar检索关键词“PKP3 antibody”、“Plakophilin 3 biomarker”等，并筛选近年高相关论文。部分经典研究可能涉及抗体开发或机制探索。
Plakophilin-3 (PKP3) is a member of the plakophilin family of armadillo-repeat proteins, primarily known for its role in cell-cell adhesion and desmosome assembly. It interacts with desmosomal cadherins (e.g., desmoglein, desmocollin) and cytoplasmic plaque proteins like desmoplakin, stabilizing epithelial and certain non-epithelial tissues. PKP3 also participates in signaling pathways, influencing cell proliferation, differentiation, and stress responses.
PKP3 antibodies are immunological tools developed to detect and study the expression, localization, and function of PKP3 in research and diagnostics. These antibodies are crucial for investigating desmosome-related pathologies, such as skin blistering disorders (e.g., pemphigus) or cancers, where PKP3 dysregulation is observed. For instance, reduced PKP3 expression correlates with poor prognosis in some carcinomas, while overexpression may drive metastasis.
Commercial PKP3 antibodies are typically produced in hosts like rabbits or mice, using immunogenic peptides from conserved regions of the human PKP3 protein. They are validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore PKP3's non-desmosomal roles, including RNA binding and transcriptional regulation, expanding its relevance in cellular dynamics.
Overall, PKP3 antibodies serve as essential reagents for unraveling the protein's dual structural and signaling roles in tissue integrity and disease.
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