| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 398, Zinc finger DNA-binding protein p52/p71, ZNF398, KIAA1339, ZER6 |
| Entrez GeneID | 57541 |
| WB Predicted band size | 71.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF398 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 amino acids from the Central region of human ZNF398. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF398抗体的3篇模拟参考文献(注：以下内容为示例，非真实文献)：
1. **文献名称**：*ZNF398 regulates transcriptional activation in colorectal cancer via interaction with β-catenin*
**作者**：Zhang Y, et al.
**摘要**：本研究利用ZNF398特异性抗体，通过ChIP-seq和Western blot分析，揭示了ZNF398在结直肠癌中通过结合β-catenin增强Wnt信号通路活性，促进肿瘤细胞增殖的机制。
2. **文献名称**：*Knockdown of ZNF398 suppresses hepatocellular carcinoma progression by modulating p53 stability*
**作者**：Wang L, et al.
**摘要**：通过免疫共沉淀(Co-IP)和免疫组化(IHC)实验，结合ZNF398抗体，研究发现ZNF398通过抑制p53泛素化降解维持其稳定性，从而在肝癌发生中发挥促癌作用。
3. **文献名称**：*ZNF398 as a novel biomarker for inflammatory response in macrophages*
**作者**：Li X, et al.
**摘要**：该研究使用ZNF398抗体进行流式细胞术和免疫荧光染色，证明ZNF398通过调控NF-κB通路激活巨噬细胞炎症反应，可能成为治疗炎症性疾病的潜在靶点。
4. **文献名称**：*ZNF398 mediates epigenetic silencing of tumor suppressors in breast cancer*
**作者**：Chen H, et al.
**摘要**：通过CRISPR/Cas9基因编辑和ZNF398抗体染色，研究发现ZNF398通过招募组蛋白去乙酰化酶(HDACs)抑制多种抑癌基因表达，促进乳腺癌转移。
(注：以上文献为假设性示例，实际研究中请通过PubMed或学术数据库检索真实文献。)
**Background of ZNF398 Antibody**
ZNF398 (Zinc Finger Protein 398), also known as ZFP398 or ZNF855. is a member of the zinc finger protein family characterized by conserved C2H2-type zinc finger domains that mediate DNA or RNA binding. It functions as a transcriptional regulator, interacting with epigenetic modifiers such as SIN3A/HDAC complexes to repress gene expression, and is implicated in cellular processes like differentiation, proliferation, and stress response. Studies link ZNF398 to cancer biology, where it may act as a tumor suppressor or oncogene depending on context—e.g., promoting DNA repair in some cancers while driving metastasis in others.
The ZNF398 antibody is a critical tool for detecting and studying this protein’s expression, localization, and molecular interactions. It is commonly used in techniques like Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and immunohistochemistry. Researchers employ this antibody to explore ZNF398’s roles in transcriptional networks, epigenetic regulation, and disease mechanisms, particularly in oncology and stem cell biology. Validated for specificity (often via knockout controls), commercially available ZNF398 antibodies are typically raised in hosts like rabbits or mice, with options targeting specific isoforms or post-translational modifications. Its utility in both basic and translational research underscores its importance in elucidating ZNF398’s context-dependent functions.
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