| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tyrosine-protein kinase FRK, Beta-cell Src-homology tyrosine kinase, BSK, FYN-related kinase, Intestine tyrosine kinase, Frk, Bsk, Iyk |
| Entrez GeneID | 14302 |
| WB Predicted band size | 58.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Frk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-491 amino acids from the C-terminal region of mouse Frk. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于小鼠Frk抗体的3篇参考文献示例，基于常见研究主题概括：
1. **"Development and characterization of a monoclonal antibody specific for mouse Frk kinase"**
*作者：Smith A, et al.*
摘要：本研究开发了一种针对小鼠Frk激酶的高特异性单克隆抗体，通过Western blot和免疫组化验证其在检测Frk表达中的应用，为研究Frk在发育和疾病中的功能提供了工具。
2. **"Frk regulates pancreatic β-cell proliferation through insulin signaling in mice"**
*作者：Chen L, et al.*
摘要：利用小鼠模型及Frk特异性抗体，研究发现Frk通过调控胰岛素受体信号通路影响β细胞增殖，抗体应用于组织切片染色和蛋白质互作分析，揭示了Frk在糖尿病中的潜在作用。
3. **"Frk deficiency alters mammary gland development in mice"**
*作者：Wang Y, et al.*
摘要：通过Frk基因敲除小鼠模型及抗体验证，发现Frk缺失导致乳腺上皮细胞分化异常，抗体用于流式细胞术和免疫沉淀，证实Frk在乳腺发育中的关键调控角色。
*注：以上为模拟文献，实际引用需通过学术数据库(如PubMed)检索具体文章。*
The Mouse Frk (fyn-related kinase) antibody is a tool used to detect and study the Frk protein, a member of the Src family tyrosine kinases (SFKs). Frk, also known as RYK (related to receptor tyrosine kinase) in some contexts, shares structural homology with other SFKs, including conserved SH2 and SH3 domains critical for protein-protein interactions and kinase activity. Unlike prototypical SFKs like Src or Fyn, Frk exhibits distinct expression patterns, predominantly localizing in epithelial tissues and playing roles in cell proliferation, differentiation, and adhesion. It has been implicated in regulating signaling pathways such as the RTK/RAS/MAPK cascade, influencing cellular responses to growth factors and stress.
Research highlights Frk’s dual role in cancer biology. In certain contexts, it acts as a tumor suppressor by inhibiting oncogenic signaling (e.g., via HER2/EGFR) or promoting apoptosis. Conversely, Frk may drive malignancy in specific cancers, underscoring its context-dependent functions. Dysregulated Frk expression correlates with outcomes in breast, pancreatic, and colorectal cancers.
The Mouse Frk antibody enables detection of endogenous Frk in mouse models, facilitating studies on its tissue distribution, phosphorylation status, and interaction partners. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. This antibody is particularly valuable for exploring Frk’s role in development, homeostasis, and disease, offering insights into therapeutic targeting of SFK-related pathways.
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