| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5 |
| Entrez GeneID | 2 |
| WB Predicted band size | 163.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This A2M antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1162-1192 amino acids from the C-terminal region of human A2M. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于A2M抗体的3篇文献示例(内容基于模拟生成，仅供参考)：
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1. **文献名称**：*Alpha-2-Macroglobulin Antibodies Enhance Clearance of Amyloid-β in Alzheimer's Disease Models*
**作者**：Bauer, J. et al.
**摘要**：研究探讨了A2M抗体在阿尔茨海默病模型中的作用，发现其通过促进小胶质细胞介导的吞噬作用，加速β-淀粉样蛋白斑块的清除，为靶向A2M的免疫治疗提供了实验依据。
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2. **文献名称**：*Targeting A2M in Tumor Microenvironments: A Novel Antibody-Based Therapeutic Strategy*
**作者**：Smith, R. & Zhang, L.
**摘要**：该文献提出A2M在肿瘤微环境中通过调节蛋白酶活性和免疫抑制信号促进癌症进展，并开发了一种特异性A2M单克隆抗体，在动物模型中显著抑制肿瘤生长和转移。
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3. **文献名称**：*A2M as a Biomarker in Rheumatoid Arthritis: Diagnostic Potential of Autoantibodies*
**作者**：Johnson, K. et al.
**摘要**：研究发现类风湿性关节炎患者血清中A2M自身抗体水平升高，且与疾病活动度相关，提示A2M抗体可能作为炎症标志物或参与自身免疫病理机制。
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4. **文献名称**：*Structural Insights into A2M-Antibody Interaction via Cryo-EM*
**作者**：Lee, S. et al.
**摘要**：通过冷冻电镜解析A2M与其单克隆抗体的复合物结构，揭示了抗体结合A2M关键功能域的分子机制，为优化抗体药物设计提供了结构基础。
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(注：以上文献及作者为虚构示例，实际研究中请通过学术数据库检索具体文献。)
Alpha-2-macroglobulin (A2M), a large plasma glycoprotein, functions as a broad-spectrum protease inhibitor and immune modulator. It traps proteases through a unique "bait-and-trap" mechanism: proteolytic cleavage triggers A2M conformational changes, encapsulating the enzyme and marking it for clearance via receptor-mediated endocytosis. This ancient protein, evolutionarily conserved across vertebrates, also regulates cytokines, growth factors, and cellular signaling pathways.
A2M antibodies have gained attention in autoimmune diseases and biomarker research. Autoantibodies against A2M are implicated in conditions like rheumatoid arthritis and lupus, potentially interfering with its protease-scavenging function and exacerbating tissue damage. Conversely, therapeutic antibodies targeting A2M are explored for modulating its activity in neurodegenerative diseases, where A2M interacts with amyloid-β and tau proteins.
In cancer, A2M overexpression correlates with tumor progression and metastasis. Antibody-based detection of A2M levels serves as a potential diagnostic/prognostic tool. Recent studies also highlight its role in immune evasion, sparking interest in A2M-targeting immunotherapies. Despite progress, the dual protective/pathogenic roles of A2M and its complex interactions with antibodies remain incompletely understood, warranting further mechanistic studies.
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