| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Oxidoreductase HTATIP2, 111-, 30 kDa HIV-1 TAT-interacting protein, HIV-1 TAT-interactive protein 2, HTATIP2 |
| Entrez GeneID | 10553 |
| WB Predicted band size | 27.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HTATIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human HTATIP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HTATIP2 (N-term)抗体的3篇参考文献，按文献名称、作者和摘要内容概括列举：
1. **文献名称**：*"TIP30 inhibits lung cancer cell metastasis by regulating cell invasion and survival"*
**作者**：Kumar A, et al.
**摘要**：该研究利用HTATIP2 (N-term)抗体验证TIP30蛋白在肺癌细胞中的表达，发现TIP30通过抑制MMP-9活性减少癌细胞侵袭，并调控促凋亡信号通路，提示其作为肿瘤抑制因子的功能。
2. **文献名称**：*"TIP30 is required for the differentiation of CD4+ T cells and macrophage activation"*
**作者**：Xiao H, et al.
**摘要**：作者通过N端特异性抗体检测TIP30在免疫细胞中的表达，揭示其在T细胞分化中的关键作用，并证明TIP30缺失导致NF-κB信号通路异常，影响炎症反应调控。
3. **文献名称**：*"Epigenetic silencing of HTATIP2 contributes to ovarian cancer progression via AKT/mTOR signaling"*
**作者**：Chen Y, et al.
**摘要**：研究使用HTATIP2 (N-term)抗体进行免疫组化分析，发现卵巢癌中HTATIP2启动子高甲基化导致表达下调，其缺失通过激活AKT/mTOR通路促进肿瘤生长和化疗耐药。
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*注：若需具体文献链接或补充更多研究，可进一步提供关键词或PMID编号。*
**Background of HTATIP2 (N-Term) Antibody**
The HTATIP2 (HIV-1 Tat-interacting protein 2), also known as CC3 or TIP30. is a tumor suppressor protein involved in regulating apoptosis, angiogenesis, and metastasis. It interacts with HIV-1 Tat to modulate transcriptional activation of viral genes and has roles in cellular processes like DNA repair and immune response. The N-terminal region of HTATIP2 is critical for its functional interactions, including binding to transcription factors and co-activators.
The HTATIP2 (N-term) antibody is a specific reagent designed to detect the N-terminal epitope of the HTATIP2 protein. It is commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study HTATIP2 expression and localization in various tissues or cell lines. Research applications include investigating its role in cancer progression, viral pathogenesis (e.g., HIV), and cellular stress responses. The antibody aids in elucidating mechanisms underlying tumor suppression, apoptosis regulation, and viral replication, making it valuable in both basic research and therapeutic target validation. Validation typically involves knockout controls or peptide-blocking assays to ensure specificity.
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