| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Calcium-activated potassium channel subunit beta-1, BK channel subunit beta-1, BKbeta, BKbeta1, Hbeta1, Calcium-activated potassium channel, subfamily M subunit beta-1, Calcium-activated potassium channel subunit beta, Charybdotoxin receptor subunit beta-1, K(VCA)beta-1, Maxi K channel subunit beta-1, Slo-beta-1, Slo-beta, KCNMB1 |
| Entrez GeneID | 3779 |
| WB Predicted band size | 21.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KCNMB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from the Central region of human KCNMB1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KCNMB1抗体的3篇参考文献示例，包括文献名称、作者及摘要概括：
1. **"Vasoregulation by the β1 subunit of the calcium-activated potassium channel"**
- **作者**: Brenner, R., et al.
- **摘要**: 该研究通过KCNMB1抗体证实β1亚基在血管平滑肌中的表达，揭示其通过增强BK通道对钙离子的敏感性调节血管张力，为高血压机制提供分子基础。
2. **"Association of the potassium channel subunit β1 with the α subunit in human smooth muscle"**
- **作者**: Pluger, S., et al.
- **摘要**: 利用KCNMB1抗体进行免疫共沉淀实验，证明β1亚基与BK通道α亚基结合，调控通道动力学特性，影响血管舒张功能。
3. **"Modulation of BK channel activity by the β1 subunit in hypertension"**
- **作者**: Amberg, G.C., et al.
- **摘要**: 通过Western blot和免疫组化分析高血压模型，发现KCNMB1表达下调导致BK通道功能受损，提示其在血管病理中的关键作用。
4. **"Localization of β1 subunit in cerebral arteries and its role in stroke"**
- **作者**: Ledoux, J., et al.
- **摘要**: 使用KCNMB1抗体进行免疫荧光定位，发现β1亚基在脑血管平滑肌的特异性分布，其缺失增加缺血性中风风险，强调其神经保护功能。
(注：以上文献为示例，实际引用时请核对真实文献信息及摘要细节。)
The KCNMB1 antibody is a crucial tool for studying the KCNMB1 protein, a regulatory subunit of the large-conductance calcium-activated potassium (BK) channel. KCNMB1. encoded by the KCNMB1 gene, modulates BK channel activity by enhancing calcium sensitivity and slowing channel deactivation, thereby influencing cellular excitability and vascular tone. These channels are vital in regulating physiological processes such as smooth muscle relaxation, neuronal firing, and hormone secretion. Dysregulation of KCNMB1 has been implicated in hypertension, asthma, epilepsy, and stroke, making it a target for therapeutic research.
The KCNMB1 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions in tissues or cell lines. It aids in understanding tissue-specific roles of KCNMB1 isoforms (e.g., β1 subunit in smooth muscle) and their pathological alterations. Researchers also employ it to explore BK channel complexes' structural-functional dynamics and their responses to pharmacological modulators.
Validating antibody specificity is critical, as cross-reactivity with other KCNMB subunits (KCNMB2-4) may occur due to sequence homology. Proper controls, such as knockout samples, ensure reliable results. Overall, the KCNMB1 antibody serves as a key reagent in cardiovascular, neurological, and metabolic studies, bridging molecular insights to potential clinical applications.
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