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Rabbit Polyclonal OR4C12 Antibody

  • 中文名： OR4C12抗体
  • 别    名： Olfactory receptor 4C12, Olfactory receptor OR11-259, OR4C12
货号: IPDX31521
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesOlfactory receptor 4C12, Olfactory receptor OR11-259, OR4C12
Entrez GeneID283093
WB Predicted band size34.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis OR4C12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-309 amino acids from the C-terminal region of human OR4C12.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于OR4C12抗体的3篇参考文献及其摘要概括(注：由于OR4C12研究较为小众，以下内容为模拟示例，实际文献需根据具体数据库检索确认)：

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1. **文献名称**：*Olfactory Receptor OR4C12 is Expressed in Human Testis and Modulates Cellular Functions*

**作者**：Smith A, et al.

**摘要**：本研究利用特异性OR4C12抗体，通过免疫组化技术首次证实OR4C12蛋白在人类睾丸组织中的表达，并发现其可能通过调节cAMP信号通路影响精子活力。抗体特异性通过Western blot和siRNA敲除实验验证。

2. **文献名称**：*Antibody-Based Detection of OR4C12 in Olfactory Neuroepithelium and Cancer Cell Lines*

**作者**：Li J, et al.

**摘要**：开发了一种高亲和力兔源多克隆OR4C12抗体，用于分析其在嗅觉上皮细胞中的定位，并意外发现某些肺癌细胞系中OR4C12的异常表达，提示其潜在肿瘤标志物功能。抗体应用包括免疫荧光和流式细胞术。

3. **文献名称**：*OR4C12 as a Novel GPCR Target: Antibody Validation and Functional Studies*

**作者**：Garcia R, et al.

**摘要**：通过肽段免疫制备OR4C12抗体，验证其在GPCR信号转导研究中的适用性。研究发现OR4C12与特定气味分子结合后可激活下游MAPK通路，抗体用于组织切片和HEK293过表达模型的蛋白检测。

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**备注**：实际研究中OR4C12抗体相关文献较少，建议通过抗体公司(如Abcam、Thermo Fisher)的产品引用列表或PubMed关键词检索获取最新文献。部分研究可能侧重基因表达分析而非抗体应用。

背景信息

The OR4C12 antibody is a research tool designed to target the olfactory receptor family 4 subfamily C member 12 (OR4C12), a G protein-coupled receptor (GPCR) primarily associated with olfactory signal transduction. Although OR4C12 is classified as an olfactory receptor, its expression is not restricted to olfactory tissues; studies suggest potential roles in non-chemosensory tissues, including the brain, testes, and certain cancers. The antibody is commonly used to investigate OR4C12's localization, expression patterns, and functional mechanisms in both physiological and pathological contexts. It is typically validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), with specificity confirmed through knockout controls or peptide-blocking assays. OR4C12's involvement in diseases, such as its reported upregulation in prostate cancer, has spurred interest in its therapeutic or diagnostic potential. However, research remains preliminary due to challenges like low endogenous protein levels and the receptor's complex ligand interactions. Commercial OR4C12 antibodies are often produced in hosts like rabbits or mice, targeting specific epitopes within the receptor’s extracellular or intracellular domains. Ongoing studies aim to clarify its ligand specificity and signaling pathways, leveraging such antibodies to explore its broader roles in cellular processes beyond olfaction.

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