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Rabbit Polyclonal MINPP1 Antibody

  • 中文名: MINPP1抗体
  • 别    名: Multiple inositol polyphosphate phosphatase 1,3-bisphosphoglycerate 3-phosphatase,3-BPG phosphatase, Inositol (1,5)-tetrakisphosphate 3-phosphatase, Ins(1,5)P(4) 3-phosphatase, MINPP1, MIPP
货号: IPDX31520
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMultiple inositol polyphosphate phosphatase 1,3-bisphosphoglycerate 3-phosphatase,3-BPG phosphatase, Inositol (1,5)-tetrakisphosphate 3-phosphatase, Ins(1,5)P(4) 3-phosphatase, MINPP1, MIPP
Entrez GeneID9562
WB Predicted band size55.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis MINPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 370-398 amino acids from the C-terminal region of human MINPP1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于MINPP1抗体的3篇参考文献示例(文献信息为模拟示例,供参考):

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1. **文献名称**: *MINPP1 regulates inositol polyphosphate metabolism and controls cellular calcium signaling in cancer cells*

**作者**: Smith J, et al.

**摘要**: 该研究利用MINPP1特异性抗体进行Western blot和免疫荧光实验,发现MINPP1通过调控肌醇磷酸代谢影响癌细胞内的钙离子动态平衡,揭示了其在肿瘤代谢中的潜在作用。

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2. **文献名称**: *Tissue-specific expression of MINPP1 revealed by immunohistochemical analysis using a novel monoclonal antibody*

**作者**: Lee H, et al.

**摘要**: 研究团队开发了一种新型MINPP1单克隆抗体,并验证其特异性。通过组织芯片分析,发现MINPP1在肝脏和肾脏中高表达,提示其与器官功能代谢密切相关。

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3. **文献名称**: *Role of MINPP1 in endoplasmic reticulum stress: Insights from antibody-based localization studies*

**作者**: García-Rodríguez R, et al.

**摘要**: 通过MINPP1抗体介导的亚细胞定位实验,发现MINPP1主要定位于内质网,并通过调节内质网应激反应影响细胞凋亡通路,为相关疾病机制研究提供新方向。

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注:以上文献信息为模拟生成,实际引用时需通过学术数据库(如PubMed、Web of Science)检索真实文献。

背景信息

The MINPP1 (Multiple Inositol Polyphosphate Phosphatase 1) antibody is a tool used to study the expression and function of the MINPP1 enzyme, a member of the inositol polyphosphate phosphatase family. MINPP1 catalyzes the hydrolysis of higher inositol phosphates (e.g., InsP6. InsP7) into lower forms, regulating intracellular inositol phosphate signaling, which influences processes like cell proliferation, apoptosis, and metabolism. It localizes primarily to the endoplasmic reticulum and plays a role in maintaining inositol phosphate homeostasis. Dysregulation of MINPP1 has been linked to cancer, neurodegenerative disorders, and metabolic diseases, making it a target for therapeutic research. The antibody is commonly used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect MINPP1 protein levels, subcellular localization, and expression changes under experimental conditions (e.g., drug treatments, gene knockdown). Available in monoclonal or polyclonal forms, it is typically validated for specificity in model organisms (e.g., human, mouse, rat). Research utilizing this antibody contributes to understanding MINPP1's role in disease mechanisms and cellular signaling pathways.

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