| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fanconi anemia group G protein, Protein FACG, DNA repair protein XRCC9, FANCG, XRCC9 |
| Entrez GeneID | 2189 |
| WB Predicted band size | 68.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FANCG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 540-568 amino acids from the C-terminal region of human FANCG. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FANCG抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**：*"Fanconi anemia proteins FANCA, FANCG, and FANCG form a nuclear complex"*
**作者**：García-Higuera, I., et al.
**摘要**：该研究通过免疫共沉淀和Western blot技术，利用FANCG抗体揭示了FANCA、FANCG和FANCF蛋白在细胞核内形成复合物的机制，为Fanconi贫血症的分子病理学提供了关键证据。
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2. **文献名称**：*"Functional interaction of monoubiquitinated FANCD2 and BRCA2 in DNA repair"*
**作者**：D'Andrea, A.D., et al.
**摘要**：研究使用FANCG抗体检测Fanconi贫血核心复合体在DNA损伤后对FANCD2单泛素化的调控作用，阐明了FANCG在BRCA2介导的同源重组修复中的协同功能。
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3. **文献名称**：*"Mutations in the Fanconi anemia gene FANCG are associated with pancreatic cancer"*
**作者**：van der Heijden, M.S., et al.
**摘要**：通过免疫组化与Western blot分析，该文献发现FANCG蛋白在胰腺癌组织中表达异常，并证实其基因突变可能通过破坏DNA修复通路促进肿瘤发生，实验中特异性FANCG抗体用于验证蛋白表达水平。
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这些研究均通过FANCG抗体探究其在DNA修复、疾病机制及肿瘤发生中的功能，涵盖基础机制与临床关联方向。如需更多文献或具体DOI号，可进一步补充研究关键词。
The FANCG antibody is a key reagent used to study the FANCG protein, a critical component of the Fanconi anemia (FA) DNA repair pathway. Fanconi anemia is a rare genetic disorder characterized by bone marrow failure, developmental abnormalities, and heightened cancer susceptibility, particularly to leukemias and solid tumors. The FA pathway, involving at least 22 FANC proteins, coordinates the repair of DNA interstrand crosslinks (ICLs) through a cascade of ubiquitination, chromatin remodeling, and homologous recombination (HR). FANCG, encoded by the *FANCG* gene, is part of the FA core complex—a multi-subunit ubiquitin ligase required for monoubiquitination of FANCD2 and FANCI. This modification enables recruitment of downstream DNA repair effectors.
Mutations in *FANCG* (located on chromosome 9p13) disrupt the FA pathway, leading to genomic instability and FA clinical phenotypes. The FANCG antibody detects endogenous FANCG protein levels, aiding in diagnostic assays, functional studies of FA pathophysiology, and research on chemotherapeutic resistance. It is widely employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, localization, and interactions within the FA core complex. Additionally, it supports investigations into crosstalk between FA proteins and other DNA damage response pathways, such as BRCA1/2-mediated HR. Research using FANCG antibodies has advanced understanding of FA molecular mechanisms and potential therapeutic strategies targeting DNA repair deficiencies.
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